Haptoglobin from human plasma, CAS No.9087-69-8

CAS: 9087-69-8 Cat. No.: np001092

QUALITÄT & REINHEIT BioReagent, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration

Accession #

P00738

Endotoxin Concentration

<2.0 EU/mg

Übersicht

An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype.
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. 

Spezifikationen

Product Name

Haptoglobin from human plasma, CAS No.9087-69-8

Synonyme

binding peptide | BP | haptoglobin alpha(1S)-beta | haptoglobin alpha(2FS)-beta | Haptoglobin | haptoglobin, alpha polypeptide | haptoglobin, beta polypeptide | HP | HP-1 | hp2-alpha | HP2ALPHA2 | HPA1S | MGC111141 | zonulin

Note

BioReagent

Spezifikationen & Reinheit

BioReagent, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration

Biochemische und physiologische Mechanismen

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also a

Endotoxin-Konzentration

<2.0 EU/mg

Beitritt #

P00738

Voraussichtliches Molekulargewicht

Hp 1-1: 86 kDa; Hp 2-1: 200 kDa; Hp 2-2: 400 kDa

CAS

9087-69-8

Molekültyp

Protein

Product Line

Biologische Produkte

Lagerung und Versand

Form

Salt-free lyophilized solid.

Konzentration

Pre-lyophilization Protein Concentration

Rekonstitution

After centrifugation, we suggest addition of de-ionized H2O to approximately the original volume (See COA), followed by gentle mixingto ensure adequate homogenization.

Storage

Store at -20°C,Avoid repeated freezing and thawing

Verschickt in

Ice chest + Ice pads

Stabilität und Lagerung

Store at -20℃ long term (>1 year). Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle.

Häufig gestellte Fragen

What is the purity of this product, and how is it determined?

This product is supplied at ≥95% purity, determined by SDS-PAGE. Lot-specific values are stated on the Certificate of Analysis.

What does BioReagent mean?

BioReagent indicates that the product has been processed and tested for biological and biochemical applications. Specifications may include endotoxin limits, microbial controls, sterility, low DNase/RNase/protease activity, and verified biological activity where relevant.

How should this product be stored?

Store at ?20 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 9087-69-8.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.