HDSF - ≥96% , CAS No.86855-26-7

CAS: 86855-26-7 Cat. No.: H331899 Summenformel: C₁₆H₃₃FO₂S Molekulargewicht: 308.5 Beilstein Registry Number: 4411921

GRADE & PURITY ≥96%

Synonyms

palmitylsulphonyl fluoride | 1-Hexadecanesulfonylfluoride | 1-Hexadecanesulfonyl fluoride | 1-HEXADECYLSULFONYL FLUORIDE | SYL-374 | Hexadecanesulfonyl fluoride | HY-125967 | AM 374 | BDBM50396293 | CHEBI:43275 | hexadecane-1-sulfonyl fluoride | Hexadecyl

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Product Describtion:

HDSF is a serine-specific, active site-directed, modifying agent that acts as an irreversible inhibitor of Cln1 (palmitoyl-protein thioesterase-1 (Ki = 125 μM)). HDSF inhibits lipase, but not phospholipase C activity in Pseudomonas aeruginosa culture supernatant and phospholipase A activity in E. coli.

Specifications

Synonyme

palmitylsulphonyl fluoride | 1-Hexadecanesulfonylfluoride | 1-Hexadecanesulfonyl fluoride | 1-HEXADECYLSULFONYL FLUORIDE | SYL-374 | Hexadecanesulfonyl fluoride | HY-125967 | AM 374 | BDBM50396293 | CHEBI:43275 | hexadecane-1-sulfonyl fluoride | Hexadecyl

Spezifikationen & Reinheit

≥96%

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥96%

Produkteigenschaften

Ki-Daten

Cln1: Ki= 125 μM

Namen und Kennungen

Pubchem Sid

488179777

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488179777

Kanonisches Lächeln

CCCCCCCCCCCCCCCCS(=O)(=O)F

IUPAC Name

hexadecane-1-sulfonyl fluoride

InChIKey

QIVFMUVBIHIZAM-UHFFFAOYSA-N

INCHI

1S/C16H33FO2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(17,18)19/h2-16H2,1H3

Isomere SMILES

CCCCCCCCCCCCCCCCS(=O)(=O)F

Molekulargewicht

308.5

Beilstein

4411921

Reaxy-Rn

4411921

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4411921&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organohalogen compounds
    • Klasse Sulfonyl halides
      • Subclass Sulfonyl fluorides

• Kingdom: Organic compounds
• Superclass: Organohalogen compounds
• Klasse: Sulfonyl halides
• Subclass: Sulfonyl fluorides
• Intermediate Tree Nodes: Not available
• Direct Parent: Sulfonyl fluorides
• Alternative Parents: Sulfonyls Organosulfonic acids and derivatives Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Sulfonyl - Sulfonyl fluoride - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Aliphatic acyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as sulfonyl fluorides. These are compounds containing a sulfonyl (R-S(=O)2-R') functional group singly bonded to a fluorine atom.
• External Descriptors: acyl fluoride

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

LPL Tchem Lipoprotein lipase (101 Activities)

Discover Target: LPL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MGLL Tchem Monoglyceride lipase (1909 Activities)

Discover Target: MGLL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zugehörige Ziele (nicht menschlich)

Faah Anandamide amidohydrolase (3907 Activities)

Discover Target: Faah

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in DMSO (10 mg/ml).
• Brechungsindex: n20D1.45 (Predicted)
• Flammpunkt (°C): 188.6ºC
• Siedepunkt (°C): 388.3ºC at 760 mmHg
• Molekulargewicht: 308.500 g/mol
• XLogP3: 7.900
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 15
• Exact Mass: 308.219 Da
• Monoisotopic Mass: 308.219 Da
• Topological Polar Surface Area: 42.500 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 283.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1