Icatibant Acetate - ≥98% , Bradykinin B2 receptor antagonist, CAS No.138614-30-9, Bradykinin B2 receptor antagonist

CAS: 138614-30-9 Cat. No.: I413312 Summenformel: C59H89N19O13Sx(C2H4O2) Molekulargewicht: 1304.52（free base） EG-Nummer: 863-000-7 PubChem CID: 5311169

GRADE & PURITY ≥98%

Synonyms

S5695 | H-D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-DL-Tic-Oic-Arg-OH.CH3CO2H | HOE 140

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Übersicht

Information

Icatibant Acetate Icatibant Acetate acts as an antagonist of the bradykinin B2 receptor and is used in the treatment of hereditary angioedema.

Targets

bradykinin B2 receptor

In vitro

Icatibant is a decapeptide resistant to the bradykinin-degrading proteases, resulting in a longer half-life than bradykinin which it antagonizes.

In vivo

Icatibant exhibits efficacy in bradykinin-mediated angioedema attacks, and induces rapid symptom relief.

Specifications

Synonyme

S5695 | H-D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-DL-Tic-Oic-Arg-OH.CH3CO2H | HOE 140

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

Icatibant Acetate acts as an antagonist of the bradykinin B2 receptor and is used in the treatment of hereditary angioedema.

Storage

Protected from light,Store at -20°C,Argon charged

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

ANTAGONIST

Mechanismus der Wirkung

Bradykinin B2 receptor antagonist

Reinheit

≥98%

Namen und Kennungen

• Pubchem Sid: 504763541
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504763541
• Kanonisches Lächeln: CC(=O)O.C1CCC2C(C1)CC(N2C(=O)C3CC4=CC=CC=C4CN3C(=O)C(CO)NC(=O)C(CC5=CC=CS5)NC(=O)CNC(=O)C6CC(CN6C(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N)O)C(=O)NC(CCCN=C(N)N)C(=O)O
• IUPAC Name: (2S)-2-[[(2S,3aS,7aS)-1-[2-[(2S)-2-[[(2S)-2-[[2-[[(2S,4R)-1-[(2S)-1-[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-ylpropanoyl]amino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid;acetic acid
• InChIKey: HKMZRZUEADSZDQ-OZPDGATDSA-N
• INCHI: 1S/C59H89N19O13S.C2H4O2/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66;1-2(3)4/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69);1H3,(H,3,4)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46?;/m0./s1
• Isomere SMILES: CC(=O)O.C1CC[C@H]2[C@@H](C1)C[C@H](N2C(=O)C3CC4=CC=CC=C4CN3C(=O)[C@H](CO)NC(=O)[C@H](CC5=CC=CS5)NC(=O)CNC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H]7CCCN7C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)N)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O
• PubChem CID: 5311169
• Molekulargewicht: 1304.52（free base）

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro
• Empfindlichkeit: Moisture sensitive；Light sensitive

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, protected from light, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 138614-30-9, the molecular formula is C59H89N19O13Sx(C2H4O2), and the molecular weight is 1304.52（free base） g/mol. InChIKey HKMZRZUEADSZDQ-OZPDGATDSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.