IEM-1460 - Moligand™, ≥98% , CAS No.121034-89-7

CAS: 121034-89-7 Cat. No.: I274744 Summenformel: C₁₉H₃₇N₂•HBr•Br Molekulargewicht: 454.33 EG-Nummer: 634-236-6 PubChem CID: 6604954

GRADE & PURITY Moligand™, ≥98%

Synonyms

HB0338 | HY-103230 | NCGC00025376-01 | Tocris-1636 | N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide | IEM1460 | IEM-1460 | SCHEMBL2489594 | C19H37BrN2.HBr | Iem 1460 | Q12071259 | DTXSID70424996 | 5-(1-a

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Übersicht

IEM 1460 is an adamantine derivative that blocks both AMPA- and NMDA-type glutamate receptor (GluR) channels (IC50 = 10 μM-0.1 mM). It is selective for Ca2+-permeable GluR channels, which lack the GluR2 R subunit, and has been used to identify Ca2+-permeable glutamate receptors in the brain.

Specifications

Synonyme

HB0338 | HY-103230 | NCGC00025376-01 | Tocris-1636 | N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide | IEM1460 | IEM-1460 | SCHEMBL2489594 | C19H37BrN2.HBr | Iem 1460 | Q12071259 | DTXSID70424996 | 5-(1-a

Spezifikationen & Reinheit

Moligand™, ≥98%

Biochemische und physiologische Mechanismen

Selective, Ca 2+ permeable GluR2-lacking AMPA receptor blocker (IC 50 values are 2.6 and 1102 μM for GluR2-lacking and GluR2-containing receptors, respectively). Blocks NMDA receptor-mediated currents. Shows anticonvulsant effects in vivo.

Storage

Store at -20°C,Desiccated

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Reinheit

≥98%

Namen und Kennungen

Kanonisches Lächeln

C[N+](C)(C)CCCCCNCC12CC3CC(C1)CC(C3)C2.Br.[Br-]

IUPAC Name

5-(1-adamantylmethylamino)pentyl-trimethylazanium;bromide;hydrobromide

InChIKey

CQTDZUSQSTUZDA-UHFFFAOYSA-M

INCHI

1S/C19H37N2.2BrH/c1-21(2,3)8-6-4-5-7-20-15-19-12-16-9-17(13-19)11-18(10-16)14-19;;/h16-18,20H,4-15H2,1-3H3;2*1H/q+1;;/p-1

Isomere SMILES

C[N+](C)(C)CCCCCNCC12CC3CC(C1)CC(C3)C2.Br.[Br-]

PubChem CID

6604954

Molekulargewicht

454.33

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Klasse Organonitrogen compounds
      • Subclass Quaternary ammonium salts

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Klasse: Organonitrogen compounds
• Subclass: Quaternary ammonium salts
• Intermediate Tree Nodes: Not available
• Direct Parent: Tetraalkylammonium salts
• Alternative Parents: Dialkylamines Organic bromide salts Hydrocarbon derivatives Hydrobromides Organic cations
• Molecular Framework: Aliphatic homopolycyclic compounds
• Substituents: Tetraalkylammonium salt - Secondary amine - Secondary aliphatic amine - Hydrocarbon derivative - Organic bromide salt - Hydrobromide - Organic salt - Amine - Organic cation - Aliphatic homopolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as tetraalkylammonium salts. These are organonitrogen compounds containing a quaternary ammonium substituted with four alkyl chains.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

Discover Target: ALOX15B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in water to 100 mM and in DMSO to 100 mM
• Empfindlichkeit: Moisture sensitive.
• Molekulargewicht: 454.300 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 8
• Exact Mass: 454.138 Da
• Monoisotopic Mass: 452.14 Da
• Topological Polar Surface Area: 12.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 301.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3