Ifosfamide (NSC109724) - Moligand™, 10mM in DMSO , DNA inhibitor, CAS No.3778-73-2, DNA inhibitor

CAS: 3778-73-2 Cat. No.: I409122 Summenformel: C₇H₁₅Cl₂N₂O₂P Molekulargewicht: 261.09 EG-Nummer: 223-237-3

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Isophosphamide | 2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Ifosfamide (NSC109724) Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer.
In vitro

Ifosfamide (50 mM) increases CYP3A4, CYP2C8, and CYP2C9 protein levels in hepatocytes, which thereby enhances their own rates of 4-hydroxylation in the cultured hepatocytes. Ifosfamide only induces CYP3A4 in one human hepatocyte culture that contained the polymorphically expressed CYP3A5 in addition to the more widely expressed CYP3A4. Ifosfamide is a prodrug metabolised in the liver by cytochrome P450 mixed-function oxidase enzymes to isofosforamide mustard, the active alkylating compound. Ifosfamide has produced favourable response rates in small cell lung cancer, paediatric solid tumours, non-Hodgkin\'s and Hodgkin\'s lymphoma, and ovarian cancer. Ifosfamide is highly cytotoxic to MCF-7 cells following stable transfection of CYP2B1 but exhibits no toxicity to parental tumor cells or to a beta-galactosidase-expressing MCF-7 transfectant, this cytotoxicity could be appreciably blocked by the CYP2B1 inhibitor metyrapone. Ifosfamide combined with Zoledronic acid is more effective than each agent alone in preventing tumor recurrence, improving tissue repair, and increasing bone formation as revealed by the analysis of trabecular architecture.

In vivo

Ifosfamide (100 mg/kg, 200 mg/kg and 400 mg/kg) injected intraperitoneally induces a dose dependent increase in bladder wet weight and Evans blue extravasation in mice. Ifosfamide reveals extensive cystitis characterized by acute inflammation with vascular congestion, edema, hemorrhage and fibrin deposition, neutrophil cell infiltration and epithelial denudation in mice. Ifosfamide shows intense reactivity to inducible nitric oxide synthase in the cytoplasm as well as intense and diffuse necrosis on hematoxylin and eosin staining.
Cell Data

cell lines：Malme-3M melanoma cells

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Synonyme

Isophosphamide | 2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

DNA inhibitor

Produkteigenschaften

ALogP

0.9

Namen und Kennungen

Isomere SMILES

C1CN(P(=O)(OC1)NCCCl)CCCl

WGK Deutschland

3

RTECS

RP6050000

Alternative CAS-Nummer

3778-73-2

NSC-Nummer

109724

MeSH-Eintrag

Asta Z 4942;Holoxan;Ifosfamide;Iphosphamide;Iso Endoxan;Iso-Endoxan;Isofosfamide;Isophosphamide;NSC 109,724;NSC 109724;NSC-109,724;NSC-109724;NSC109,724;NSC109724

Molekulargewicht

261.09

Reaxy-Rn

5802893

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5802893&ln=

Chemische und physikalische Eigenschaften

• Schmelzpunkt (°C): 42 °C

Häufig gestellte Fragen

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 3778-73-2, the molecular formula is C7H15Cl2N2O2P, and the molecular weight is 261.09 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.