GRADE & PURITY Moligand™, ≥99%

Synonyms

2,7-Difluorospiro[9H-fluorene-9,4'-imidazolidine]-2',5'-dione | AL-1576 | HOE-843 | 2,7-Difluorospiro[Fluorene-9,4'-IMidazolidine]-2',5'-Dione | Alcon1576 | 2,7-Difluoro-2'H,5'H-spiro[fluorene-9,4'-imidazolidine]-2',5'-dione | Spiro[9H-fluorene-9,4'-imida

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.

In Vivo

Imirestat (1 mg/kg) improves nerve conduction velocity but is without effect upon the resistance to hypoxic conduction blockade or the deficit in insulin-stimulated oubain-sensitive ATPase activity . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Synonyms

2, 7-Difluorospiro[9H-fluorene-9, 4'-imidazolidine]-2', 5'-dione | AL-1576 | HOE-843 | 2, 7-Difluorospiro[Fluorene-9, 4'-IMidazolidine]-2', 5'-Dione | Alcon1576 | 2, 7-Difluoro-2'H, 5'H-spiro[fluorene-9, 4'-imidazolidine]-2', 5'-dione | Spiro[9H-fluorene-9, 4'-imida

Specifications & Purity

Moligand™, ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Isomeric SMILES: C1=CC2=C(C=C1F)C3(C4=C2C=CC(=C4)F)C(=O)NC(=O)N3
• PubChem CID: 65673
• Molecular Weight: 286.23

Associated Targets(Human)

AKR1B1 Tclin Aldose reductase (1 Activities)

Discover Target: AKR1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1B1 Tclin Aldose reductase (1404 Activities)

Discover Target: AKR1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO : 83.33 mg/mL (291.13 mM; Need ultrasonic)
• Molecular Weight: 286.230 g/mol
• XLogP3: 2.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 286.055 Da
• Monoisotopic Mass: 286.055 Da
• Topological Polar Surface Area: 58.200 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 472.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1