Insulin Icodec, CAS No.1188379‑43‑2

CAS: 1188379‑43‑2 Cat. No.: I1527922

GRADE & PURITY Recombinant, PharmPure™, Lyophilized powder, ≥99%, xpressed in Pichia pastoris；Potency: 16.7-33.3 U/mg

Accession #

P01308

Expression system

Pichia pastoris

Endotoxin Concentration

<1.5 EU/mg

Bioactivity

16.7-33.3 U/mg

Übersicht

Insulin Icodec is a once‑weekly ultra‑long‑acting basal insulin analog. It binds strongly and reversibly to human serum albumin and exhibits a long plasma half‑life. Insulin Icodec modulates insulin receptor activity, controls blood glucose levels and reduces HbA1c levels. It is used to study hyperglycemia caused by type 1 and type 2 diabetes, and can be applied in researches of type 1 and type 2 diabetes.

Structure: Insulin Icodec consists of two peptide chains. The A‑chain contains 21 amino acids with A14 substitution. The B‑chain lacks threonine at position B30 compared with human insulin B‑chain and contains 29 amino acids with substitutions at B16 and B25. The ε‑amino group of Lys(B29) forms an amide bond with the modifying side‑chain: L‑γ‑glutamic acid‑two oligo‑ethylene glycol units‑icosanedioic diacid. Three conserved disulfide‑bonds: A6‑A11, A7‑B7, A20‑B19.

Molecular formula: C₂₈₀H₄₃₅N₇₁O₈₇S₆

Molecular weight: 6380.26

Schematic Diagram: 

Specifications

Product Name

Insulin Icodec, CAS No.1188379‑43‑2

Note

Lyophilized powder, PharmPure™, Recombinant

Spezifikationen & Reinheit

Recombinant, PharmPure™, Lyophilized powder, ≥99%, xpressed in Pichia pastoris；Potency: 16.7-33.3 U/mg

Bioaktivität

16.7-33.3 U/mg

Endotoxin-Konzentration

<1.5 EU/mg

Sequenz

A-chain： Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Glu-Gln-Leu-Glu-Asn-Tyr-Cys-Asn B‑chain： Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-His-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-His-Tyr-Thr-Pro-Lys (Disulfide bridge: A6-A11, A7-B7, A20-B19)

Beitritt #

P01308

Voraussichtliches Molekulargewicht

6380.26

CAS

1188379‑43‑2

Product Line

biological_products

Lagerung und Versand

Konzentration

xpressed in Pichia pastoris；Potency: 16.7-33.3 U/mg

Rekonstitution

Reconstitute in water for injection.

Storage

Protected from light,Store at -20°C,Desiccated,Avoid repeated freezing and thawing

Verschickt in

Ice chest + Ice pads

Stabilität und Lagerung

Store at -20℃ long term (36 months). Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle. Store in the dark. Desiccated.

Definition der Einheit

One Unit (U) of insulin icodec has hypoglycemic biological activity equivalent to 1 International Unit (IU) of human insulin.