Istaroxime hydrochloride - ≥98% , CAS No.374559-48-5

CAS: 374559-48-5 Cat. No.: I648885 Summenformel: C₂₁H₃₃ClN₂O₃ Molekulargewicht: 396.95 PubChem CID: 72941813

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Übersicht

Istaroxime hydrochloride is a Na + /K + -ATPase inhibitor ( IC 50 =0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ( SERCA 2 ) activator.

In Vitro

Istaroxime hydrochloride acting as a positive inotropic compound through the inhibition of the Na + ,K + -ATPase. Istaroxime (PST2744) inhibits the Na + /K + -ATPase activity from dog kidney with an IC 50 value of 0.43 ± 0.15 μM. Inhibition of Na + /K + -ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Istaroxime (PST2744) induces a progressive increase in +dP/dt max throughout the infusion that reaches 80% (ED 80 ) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (ED max ) of 4.88±0.6 mg/kg. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 0.11 μM (Na + ,K + -ATPase)

Specifications

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

Istaroxime hydrochloride is a Na + /K + -ATPase inhibitor ( IC 50 =0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ( SERCA 2 ) activator.

Storage

Store at 2-8°C,Desiccated

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥98%

Namen und Kennungen

Isomere SMILES

C[C@]12CCC(=NOCCN)C[C@@H]1C(=O)C[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4=O)C.Cl

PubChem CID

72941813

Molekulargewicht

396.95

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : ≥ 45 mg/mL (113.36 mM) H2O : 25 mg/mL (62.98 mM; Need ultrasonic)

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 374559-48-5, the molecular formula is C21H33ClN2O3, and the molecular weight is 396.95 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.