Ivacaftor-d4 - ≥96% , CAS No.I658675

CAS: I658675 Cat. No.: I658675 Summenformel: C₂₄H₂₄D₄N₂O₃ Molekulargewicht: 396.52

QUALITÄT & REINHEIT ≥96%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Übersicht

Ivacaftor-d4 (VX-770-d4) is the deuterium labeled-Ivacaftor ( HY-13017 ). Ivacaftor is a potent and orally active CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC 50 s of 100 nM and 25 nM, respectively.

Appearance:Solid

In Vitro:Ivacaftor (10 μM) increases the PC secretion activity by 3-fold for ABCB4-G535D, 13.7-fold for ABCB4-G536R, 6.7-fold for ABCB4-S1076C, 9.4-fold for ABCB4-S1176L, and 5.7-fold for ABCB4-G1178S. Ivacaftor corrects the functional defect of ABCB4 mutants

In Vivo:Ivacaftor (1-200mg/kg, p.o.) exhibits good oral bioavailability in rat. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biological Activity:Ivacaftor-d4 (VX-770-d4) is the deuterium labeled-Ivacaftor ( HY-13017 ). Ivacaftor is a potent and orally active CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC 50 s of 100 nM and 25 nM, respectively .

Spezifikationen

Spezifikationen & Reinheit

≥96%

Storage

Store at 2-8°C,Desiccated

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

AGONIST

Reinheit

≥96%

Namen und Kennungen

Molekulargewicht

396.52

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥96% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is I658675, the molecular formula is C24H24D4N2O3, and the molecular weight is 396.52 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.