J22352 - 10mM in DMSO , CAS No.2252395-44-9

CAS: 2252395-44-9 Cat. No.: J656839 Summenformel: C₂₄H₂₁N₃O₄ Molekulargewicht: 415.44 PubChem CID: 138377601

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC 50 value of 4.7 nM. J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and leading to the restoration of host antitumor activity by reducing the immunosuppressive activity of PD-L1

In Vitro

J22352 (0.1-20 μM; 72 hours) decreases U87MG cell viability in a dose-dependent manner. J22352 (10 μM; 24 hours) shows a dose-dependent decrease in HDAC6 protein abundance. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: U87MG cells Concentration: 0.1 μM; 0.5 μM; 1μM; 2.5 μM; 5 μM; 10 μM; 20 μM Incubation Time: 72 hours Result: A dose-dependent decrease on U87MG cell proliferation. Western Blot AnalysisCell Line: U87MG cells Concentration: 10 μM Incubation Time: 24 hours Result: A dose-dependent decrease in aberrant overexpression of HDAC6 in glioblastoma.

In Vivo

J22352 (10 mg/kg; given i.p. per day for 14 days in male nude mice) results in a >80% tumor growth inhibition (TGI) rate. J22352 is well tolerated in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male nude mice (BALB/cAnN.Cg-Foxnlnu/CrlNarl, 4-6 weeks old) Dosage: 10 mg/kg Administration: Given i.p.; per day for 14 days Result: Marked anti-tumor effects and well tolerated in mice.

IC50& Target:HDAC6 4.7 nM (IC 50 )

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC 50 value of 4.7 nM. J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune respon

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

• Isomere SMILES: C1=CC=C(C=C1)CCN2C(=O)C3=CC=CC=C3N(C2=O)CC4=CC=C(C=C4)C(=O)NO
• PubChem CID: 138377601
• Molekulargewicht: 415.44

Zugehörige Ziele (menschlich)

HDAC6 Tclin Histone deacetylase 6 (4 Activities)

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC8 Tclin Histone deacetylase 8 (1 Activities)

Discover Target: HDAC8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2252395-44-9, the molecular formula is C24H21N3O4, and the molecular weight is 415.44 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.