K252b - ≥97%(HPLC) , CAS No.99570-78-2

CAS: 99570-78-2 Cat. No.: K139556 Summenformel: C26H19N3O5 Molekulargewicht: 453.5
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GRADE & PURITY ≥97%(HPLC)
Synonyms
(5S,6R,8R)-6-Hydroxy-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6-carboxylic acid | AKOS030254879 | (5S,6R,8R)-6-Hydroxy-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-
Storage
Lagerung bei -20°C
Shipped In
Eistruhe + Eispads
★
Size
Deutschland (EU)
USA*
Price
Qty
100μg
K139556-100μg
—
1 Auf Lager
367,83€
1mg
K139556-1mg
Auf Bestellung · 8–12 Wochen
1.226,90€
5mg
K139556-5mg
Auf Bestellung · 8–12 Wochen
5.286,18€
Enter a quantity for the sizes you want to add.
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Why this grade

≥97%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Lagerung bei -20°C Ships Eistruhe + Eispads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Übersicht

K252B: ein Inhibitor der Proteinkinase A, C, G K-252b ist ein allgemeiner, zelldurchlässiger Proteinkinase-Inhibitor, der durch Bindung an die ATP-Bindungsdomäne der Kinase wirkt. K-252b ist ein starker Inhibitor von CaMKII (Ca2+/Calmodulin-Kinase II), MYLK (Myosin-Leichtkettenkinase, Ki=0,147 μM), PKA (cAMP-abhängige Proteinkinase, Ki=0,09 μM), PKC (Proteinkinase C, Ki=0,02 μM) und cGKI (cGMP-abhängige Proteinkinase, Ki=0,1 μM).
Ein Antibiotikum und ein starker Inhibitor der Proteinkinase C (PKC)

Specifications

Synonyme
(5S,6R,8R)-6-Hydroxy-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6-carboxylic acid | AKOS030254879 | (5S,6R,8R)-6-Hydroxy-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-
Spezifikationen & Reinheit
≥97%(HPLC)
Storage
Lagerung bei -20°C
Verschickt in
Eistruhe + Eispads
Aktionsart
INHIBITOR
Reinheit
≥97%(HPLC)
Namen und Kennungen
Pubchem Sid
Kanonisches Lächeln
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
IUPAC Name
(15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylic acid
InChIKey
AMSOPBXQXSAAAC-PLZPTFKGSA-N
INCHI
1S/C26H19N3O5/c1-25-26(33,24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9,17,33H,10-11H2,1H3,(H,27,30)(H,31,32)/t17-,25+,26+/m1/s1
Isomere SMILES
C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
Molekulargewicht
453.5
Reaxy-Rn
8174680
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8174680&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
KlasseIndoles and derivatives
SubclassCarbazoles
Intermediate Tree Nodes Pyrrolocarbazoles
Direct ParentIndolocarbazoles
Alternative Parents Pyrrolo[2,3-a]carbazoles  Pyrroloindoles  Isoindolones  Indoles  Alpha hydroxy acids and derivatives  Benzenoids  Tertiary alcohols  Heteroaromatic compounds  Pyrroles  Oxolanes  Lactams  Secondary carboxylic acid amides  Azacyclic compounds  Carboxylic acids  Monocarboxylic acids and derivatives  Oxacyclic compounds  Carbonyl compounds  Hydrocarbon derivatives  Organic oxides  Organonitrogen compounds  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Indolocarbazole - Pyrrolo[2,3-a]carbazole - Pyrroloindole - Isoindolone - Indole - Isoindoline - Isoindole or derivatives - Alpha-hydroxy acid - Hydroxy acid - Benzenoid - Pyrrole - Oxolane - Tertiary alcohol - Heteroaromatic compound - Secondary carboxylic acid amide - Lactam - Carboxamide group - Oxacycle - Azacycle - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Carboxylic acid - Organooxygen compound - Organic nitrogen compound - Alcohol - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Carbonyl group - Organonitrogen compound - Aromatic heteropolycyclic compound
BeschreibungThis compound belongs to the class of organic compounds known as indolocarbazoles. These are polycyclic aromatic compounds containing an indole fused to a carbazole.
External Descriptors Not available
3D-Struktur
Interaktives chemisches Strukturmodell





Wirkungsmechanismen
Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot NumberCertificate TypeDatumArtikel
K1907154Certificate of AnalysisSep 05, 2023 K139556
Chemische und physikalische Eigenschaften
LöslichkeitSoluble in DMSO (1 mg/ml), DMF (1 mg/ml), and methanol (2 mg/ml).
EmpfindlichkeitLight & Air Sensitive & Hygroscopic
Siedepunkt (°C)769.82 °C at 760 mmHg
Schmelzpunkt (°C)318.16°C
Molekulargewicht453.400 g/mol
XLogP32.400
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass453.132 Da
Monoisotopic Mass453.132 Da
Topological Polar Surface Area106.000 Ų
Heavy Atom Count34
Formal Charge0
Complexity961.000
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Lösungsrechner
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