KRpep-2d - ≥99% , CAS No.K414030

CAS: K414030 Cat. No.: K414030 Summenformel: CO₈H₁₈₂N₄₄O₂₅S₂ Molekulargewicht: 2561.01

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Information

KRpep-2d KRpep-2d is a K-Ras(G12D) selective inhibitory cyclic peptide with selectivity against wild-type (WT) K-Ras and the K-Ras(G12C) mutant. The IC50 value is 1.6 nM.

Targets

K-Ras(G12D) (Cell-free assay) 1.6 nM

In vitro

KRpep-2d binds to K-Ras（G12D）with a Kd of 8.9 nM and approximately 6-fold selectivity over WT K-Ras, leading to an extended dissociation half-life. KRpep-2d significantly suppresses ERK-phosphorylation, downstream of K-Ras(G12D), along with A427 cancer cell proliferation at 30 μM peptide concentration.

Cell Research(from reference)

Cell lines：A427 (lung, G12D mutant) and A549 (lung, G12C mutant) cells 

Concentrations：0, 0.3, 3, 30 μM 

Incubation Time：3 days 

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

KRpep-2d is a K-Ras(G12D) selective inhibitory cyclic peptide with selectivity against wild-type (WT) K-Ras and the K-Ras(G12C) mutant. The IC50 value is 1.6 nM.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥99%

Namen und Kennungen

• Molekulargewicht: 2561.01

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro Water: 100 mg/mL (39.04 mM)

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is K414030, the molecular formula is CO8H182N44O25S2, and the molecular weight is 2561.01 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.