L-AP4 monohydrate - ≥99% , CAS No.2247534-79-6

CAS: 2247534-79-6 Cat. No.: L648058 Summenformel: C₄H₁₂NO₆P Molekulargewicht: 201.11

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Übersicht

L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs , with EC 50 s of 0.13, 0.29, 1.0, 249 μM for mGlu 4 , mGlu 8 , mGlu 6 and mGlu 7 receptors, respectively

In Vivo

L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction. Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats. Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rats.Dosage: 5-30 μg. Administration: Intrathecal inhection 4-5 days. Result: Dose-dependently increased paw withdrawal threshold.

Form:Solid

IC50& Target:mGlu 4 0.13 μM (EC 50 ) mGlu8 0.29 μM (EC 50 ) mGlu 6 1.0 μM (EC 50 ) mGlu7 249 μM (EC 50 )

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs , with EC 50 s of 0.13, 0.29, 1.0, 249 μM for mGlu 4 , mGlu 8 , mGlu 6 and mGlu 7 receptors, respectively.

Storage

Store at 2-8°C,Protected from light,Desiccated

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

AGONIST

Reinheit

≥99%

Namen und Kennungen

• Molekulargewicht: 201.11

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2247534-79-6, the molecular formula is C4H12NO6P, and the molecular weight is 201.11 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.