L-Thyroxine(T4) - Moligand™, 10mM in DMSO , Agonist of Thyroid hormone receptor-α;Agonist of Thyroid hormone receptor-β, CAS No.51-48-9, Agonist of Thyroid hormone receptor-α;Agonist of Thyroid hormone receptor-β

CAS: 51-48-9 Cat. No.: L408317 Molecular Weight: 776.87 Beilstein Registry Number: 2228515 EC Number: 200-101-1 PubChem CID: 5819

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

NSC 36397 | O-​(4-​hydroxy-​3,​5-​diiodophenyl)​-​3,​5-​diiodo-L-​tyrosine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

L-Thyroxine (NSC 36397) is a synthetic form of thyroxine and a hormone replacement drug.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Synonyms

NSC 36397 | O-​(4-​hydroxy-​3, ​5-​diiodophenyl)​-​3, ​5-​diiodo-L-​tyrosine

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

L-Thyroxine (NSC 36397) is a synthetic form of thyroxine and a hormone replacement drug.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of Thyroid hormone receptor-α;Agonist of Thyroid hormone receptor-β

Names and Identifiers

• Isomeric SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)O)N
• PubChem CID: 5819
• Molecular Weight: 776.87
• Beilstein: 2228515

Associated Targets(Human)

THRA Tclin Thyroid hormone receptor alpha (1 Activities)

Discover Target: THRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THRB Tclin Thyroid hormone receptor beta (1 Activities)

Discover Target: THRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Melt Point(°C): 223°C

References

1. Xinyi Li, Kaiyue Li, Jiayi Li, Zhiqin Zhang, Hongyuan Wang.  (2023)  Effects of perchlorate and exogenous T4 on growth, development and tail resorption of Rana chensinensis.  ENVIRONMENTAL POLLUTION,      [PMID:37558196] [10.1016/j.envpol.2023.122333]

2. Yangyang Wang, Yanping Sun, Bingyou Yang, Qiuhong Wang, Haixue Kuang.  (2022)  Integrate metabolomics strategy and target prediction to reveal the ameliorate effect of four typical ‘cold’ property herbs on hyperthyroidism rats.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:36202164] [10.1016/j.jep.2022.115772]

3. Wang Yang-Yang, Sun Yan-Ping, Yang Bing-You, Wang Qiu-Hong, Kuang Hai-Xue.  (2022)  Application of metabolomics and network analysis to reveal the ameliorating effect of four typical “hot” property herbs on hypothyroidism rats.  Frontiers in Pharmacology,      [PMID:36091783] [10.3389/fphar.2022.955905]

4. Quan Chi, Wenxiang Zhang, Lang Wang, Juan Huang, Ming Yuan, Huaming Xiao, Xian Wang.  (2019)  Evaluation of structurally different brominated flame retardants interacting with the transthyretin and their toxicity on HepG2 cells.  CHEMOSPHERE,      [PMID:31927367] [10.1016/j.chemosphere.2019.125749]

5. Mei Yang, Youning Ma, Wenjun Gui, Yiping Ren, Guonian Zhu, Yihua Liu.  (2015)  Determination of 26 endocrine disrupting chemicals in fish and water using modified QuEChERS combined with solid-phase extraction and UHPLC-MS/MS.  Analytical Methods,  7  (19): (8418-8431).  [PMID:] [10.1039/C5AY01082A]

6. Fei Wei, Xueyi Wu, Hongyuan Wang, Yongpu Zhang, Lei Xie.  (2025)  Methimazole disrupted skeletal ossification and muscle fiber transition in Bufo gargarizans larvae.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:39793290] [10.1016/j.ecoenv.2025.117684]

7. Ting Tai, Yuan-Yuan Shao, Yu-Qi Zheng, Li-Ping Jiang, Hao-Ru Han, Na Yin, Hao-Dong Li, Jin-Zi Ji, Qiong-Yu Mi, Li Yang, Lei Feng, Fu-Yang Duan, Hong-Guang Xie.  (2024)  Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond.  Frontiers in Pharmacology,      [PMID:39508046] [10.3389/fphar.2024.1496639]

8. Lei Xie, Ziyi Niu, Shimin Xiao, Hongyuan Wang, Yongpu Zhang.  (2024)  Morphological and Transcriptomic Analyses Reveal the Toxicological Mechanism and Risk of Nitrate Exposure in Bufo gargarizans Embryos.  Animals,  14  (6): (961).  [PMID:38540059] [10.3390/ani14060961]

9. Zhilin Yang, Nan Yuan, Yaning Gong, Yang Jiao, Najun Li, Jianmei Lu.  (2025)  High-Concentrated Reactive Oxygen Species from Chiral Thyroxine for Piezocatalytic Antitumor Therapy.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202519435]

10. Shengxian Liang, Shaojun Liang, Nuoya Yin, Francesco Faiola.  (2019)  Establishment of a human embryonic stem cell-based liver differentiation model for hepatotoxicity evaluations.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:30849655] [10.1016/j.ecoenv.2019.02.091]

11. Pingfa Gao, Lyuping Hu, Songzhou Lu, Dongxu Feng, Yingying Wang, Zhewei Fei, Wei Wu.  (2025)  Levothyroxine suppression therapy improves maternal and neonatal outcomes in pregnancy after thyroidectomy for differentiated thyroid carcinoma.  American Journal of Translational Research,  17  (11): (8643).  [PMID:41415087] [10.62347/UTCU8727]