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LCAHA - ≥98% , CAS No.117094-40-3
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC 50 s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a.
In Vitro
LCAHA inhibits HCT116 wt and HCT116 p53 -/- colon cancer cells viability with GI 50 s of 0.87±0.09 and 0.96±0.29μM, respectively, and the LD 50 s of 27.8±3.9 and 26.5±0.1μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCT116 wt and HCT116 p53 -/- colon cancer cells Concentration: 0.01, 0.1, 1, 10, and 100 μM Incubation Time: 6 days Result: The GI 50 s are 0.87±0.09 and 0.96±0.29 μM for HCT116 wt and HCT116 p53 -/- colon cancer cells, respectively.
Form:Solid
Specifications
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC 50 s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥98%
Names and Identifiers
| Molecular Weight | 391.59 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 45 mg/mL (114.92 mM; Need ultrasonic) |
|---|
Solution Calculators
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