Leelamine - Moligand™, 10 mM in DMSO , CAS No.1446-61-3

CAS: 1446-61-3 Cat. No.: L1500204 Molecular Weight: 285.48 EC Number: 215-899-7

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Leelamine is an orally active pyruvate dehydrogenase kinase ( PDK ) inhibitor with an IC 50 value of 9.5 μM,showing a blood glucose lowering effect in the diabetic mouse. Leelamine is also a weak agonist of cannabinoid receptors CB1 and CB2 . Leelamine decreases mitotic activity, prostate-specific antigen expression and induces Apoptosis to cell death in cancer cells.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Names and Identifiers

• Isomeric SMILES: CC(C)C1=CC2=C(C=C1)[C@]3(CCC[C@@]([C@@H]3CC2)(C)CN)C
• Molecular Weight: 285.48
• Reaxy-Rn: 2383194
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2383194&ln=

Chemical and Physical Properties

• Specific Rotation[α]: 45° (C=4,MeOH)
• Melt Point(°C): 40 °C

References

1. Shiyu Wu, Yufu Yi, Shengliang Liao, Hongyan Si, Yuling Yang, Guorong Fan, Peng Wang.  (2021)  Synthesis and Shape-Selective Catalytic Application of Ordered Cubic Ia3̅d Supermicroporous Materials Templated by Rosin-Derived Quaternary Ammonium Salt with a Hydroxyl Radical in the Headgroup.  LANGMUIR,      [PMID:33397112] [10.1021/acs.langmuir.0c03356]

2. Xiaoyun Liu, Ruhong Zhang, Tianquan Li, Pengfei Zhu, Qixin Zhuang.  (2017)  Novel Fully Biobased Benzoxazines from Rosin: Synthesis and Properties.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.7b02650]