LGD-6972 - Moligand™, 10mM in DMSO , CAS No.1207989-09-0

CAS: 1207989-09-0 Cat. No.: L655135 Summenformel: C₄₃H₄₆N₂O₅S Molekulargewicht: 702.90 PubChem CID: 44625560

QUALITÄT & REINHEIT Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

LGD-6972 is a selective and orally active Glukagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research.

In Vitro

In vitro, LGD-6972 binds competitively to Glukagon receptor (GCGR) with high affinity and selectivity, suppressing both cAMP and glucose production. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In vivo, LGD-6972 reduces acute Glukagon-stimulated hyperglycaemia as well as the hyperglycaemia observed in diabetic mouse models. The pharmacological activity of LGD-6972 appears to be mediated primarily by inhibiting Glukagon receptor signaling . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Spezifikationen

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

LGD-6972 is a selective and orally active Glukagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Namen und Kennungen

Isomere SMILES

CC1=CC(=C(C(=C1)C)C2=CC=C(C=C2)NC(=O)[C@H](CC3=CC=C(C=C3)C(=O)NCCS(=O)(=O)O)C4=CC=C(C=C4)C5=CC=C(C=C5)C(C)(C)C)C

Alternative CAS-Nummer

1207989-09-0

PubChem CID

44625560

MeSH-Eintrag

2-((4-((2R)-2-(4-(4-tert-butylphenyl)phenyl)-3-oxo-3-(4-(2,4,6-trimethylphenyl)anilino)propyl)benzoyl)amino)ethanesulfonic acid;LGD-6972;RVT-1502

Molekulargewicht

702.90