Linrodostat (BMS-986205) - Moligand™, 10mM in DMSO , Inhibitor of indoleamine 2;3-dioxygenase 1, CAS No.1923833-60-6, Inhibitor of indoleamine 2;3-dioxygenase 1

CAS: 1923833-60-6 Cat. No.: L408060 Summenformel: C₂₄H₂₄ClFN₂O Molekulargewicht: 410.91

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

ONO-7701 | Cyclohexaneacetamide​, N-​(4-​chlorophenyl)​-​4-​(6-​fluoro-​4-​quinolinyl)​-​α-​methyl-​, cis-​(αR)​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Linrodostat (BMS-986205) Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptopha
In vitro

BMS-986205 exhibits potent inhibition of kynurenine (kyn) production in IDO1-HEK293 cells (IC50 = 1.1 nM) but not in TDO-HEK293 cells. It is an irreversible suicide inhibitor.

In vivo

Cell Data

cell lines：KMS11 and KMS18

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyme

ONO-7701 | Cyclohexaneacetamide​, N-​(4-​chlorophenyl)​-​4-​(6-​fluoro-​4-​quinolinyl)​-​α-​methyl-​, cis-​(αR)​-

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Inhibitor of indoleamine 2;3-dioxygenase 1

Namen und Kennungen

• Isomere SMILES: C[C@H](C1CCC(CC1)C2=C3C=C(C=CC3=NC=C2)F)C(=O)NC4=CC=C(C=C4)Cl
• Alternative CAS-Nummer: 1923833-60-6
• MeSH-Eintrag: (2R)-N-(4-Chlorophenyl)-2-(cis-4-(6-fluoro-4-quinolinyl)cyclohexyl)propanamide;BMS-986205;Cyclohexaneacetamide, N-(4-chlorophenyl)-4-(6-fluoro-4-quinolinyl)-\u03b1-methyl-, cis-;linrodostat
• Molekulargewicht: 410.91
• Reaxy-Rn: 39662458
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=39662458&ln=

Zugehörige Ziele (menschlich)

IDO1 Tchem Indoleamine 2,3-dioxygenase 1 (0 Activities)

Discover Target: IDO1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Häufig gestellte Fragen

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1923833-60-6, the molecular formula is C24H24ClFN2O, and the molecular weight is 410.91 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.