Liproxstatin-1 - Moligand™, ≥97% , CAS No.950455-15-9

CAS: 950455-15-9 Cat. No.: L413818 Summenformel: C₁₉H₂₁ClN₄ Molekulargewicht: 340.85

GRADE & PURITY Moligand™, ≥97%

Synonyms

N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine | N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4'-piperidine]-2-amine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Information

Liproxstatin-1 Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.

Targets

ferroptosis (Cell-free assay) 22 nM

In vitro

Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4^−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4^−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H₂O₂ (200 µM).

In vivo

Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury.

Cell Research(from reference)

Cell lines：Gpx4^−/−cells 

Concentrations：~200 nM 

Incubation Time：~72 h 

Specifications

Synonyme

N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine | N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4'-piperidine]-2-amine

Spezifikationen & Reinheit

Moligand™, ≥97%

Biochemische und physiologische Mechanismen

Liproxstatin-1 is a potent inhibitor of iron death, a non apoptotic form of cell death characterized by iron dependent lethal accumulation of lipid reactive oxygen species (ROS). Liproxstatin-1 inhibited iron death in human cells and ischemia / reperfusio

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Reinheit

≥97%

Produkteigenschaften

• ALogP: 2.598
• hba_count: 1
• HBD-Zahl: 3
• Rotationsfähige Bindung: 3

Namen und Kennungen

• Pubchem Sid: 504773420
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773420
• Kanonisches Lächeln: C1CNCCC12C(=NCC3=CC(=CC=C3)Cl)NC4=CC=CC=C4N2
• IUPAC Name: N-[(3-chlorophenyl)methyl]spiro[1,4-dihydroquinoxaline-3,4'-piperidine]-2-imine
• InChIKey: YAFQFNOUYXZVPZ-UHFFFAOYSA-N
• INCHI: 1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
• Isomere SMILES: C1CNCCC12C(=NCC3=CC(=CC=C3)Cl)NC4=CC=CC=C4N2
• Molekulargewicht: 340.85
• Reaxy-Rn: 34084241
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=34084241&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Diazanaphthalenes
      • Subclass Benzodiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Quinoxalines
• Alternative Parents: Benzylamines Secondary alkylarylamines Chlorobenzenes Piperidines Imidolactams Aryl chlorides Propargyl-type 1,3-dipolar organic compounds Dialkylamines Carboxamidines Azacyclic compounds Organochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Quinoxaline - Benzylamine - Chlorobenzene - Halobenzene - Secondary aliphatic/aromatic amine - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Piperidine - Imidolactam - Benzenoid - Azacycle - Secondary aliphatic amine - Carboxylic acid amidine - Amidine - Organic 1,3-dipolar compound - Secondary amine - Propargyl-type 1,3-dipolar organic compound - Organonitrogen compound - Organochloride - Organohalogen compound - Hydrocarbon derivative - Organic nitrogen compound - Amine - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as quinoxalines. These are compounds containing a quinoxaline moiety, a bicyclic heterocycle made up of a benzene ring fused to a pyrazine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

MRC5 (9203 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zugehörige Ziele (nicht menschlich)

Trypanosoma brucei brucei (13300 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro Ethanol: 4 mg/mL warmed with 50ºC Water: bath (11.73 mM); DMSO: Insoluble; Water: Insoluble
• DMSO (mg/ml) Maximale Löslichkeit: 68
• DMSO (mM) Maximale Löslichkeit: 199.5012469
• Wasser (mg/ml) Maximale Löslichkeit: ＜1
• Molekulargewicht: 340.800 g/mol
• XLogP3: 3.200
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 340.145 Da
• Monoisotopic Mass: 340.145 Da
• Topological Polar Surface Area: 48.500 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 460.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referenzen

1. Lei Shu, Peili Luo, Chuanyu Ren, Ziwei Lai, Xuejuan Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang.  (2025)  Inhalable Fibroin Hybrid Liposomes for the Targeted Treatment of Lung Adenocarcinoma via Autophagy-Enhanced Ferroptosis.  ACS Nano,      [PMID:40878028] [10.1021/acsnano.5c09493]

2. Jing Lin, Xueli Yang, Cizhong Jiang, Xiaoguang Liu, Jiejun Shi.  (2026)  Enhancing cancer susceptibility to disulfidptosis by inducing cell cycle arrest and impairing DNA repair.  Theranostics,  16  (2): (637).  [PMID:41346703] [10.7150/thno.122956]

3. Jiao Kong, Yujia Chen, Shuanghui Lu, Lvexiang Yuan, Tao He, Minlei Dong, Yingqiong Zhang, Xiaoyi Pan, Hui Zhou, Huidi Jiang.  (2026)  Pollen of Brassica campestris L. ameliorates hyperuricemic and obstructive nephropathy by targeting the β-catenin/TCF4-ferroptosis pathway.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:41933742] [10.1016/j.jep.2026.121611]