LM22A-4 - 10mM in DMSO , CAS No.37988-18-4

CAS: 37988-18-4 Cat. No.: L423720 Summenformel: C₁₅H₂₁N₃O₆ Molekulargewicht: 339.34

GRADE & PURITY 10mM in DMSO

Synonyms

LM 22A4 | LM22a4 | LM-22A4 | LM22A-4 | N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide | 5GCL3P6AF5 | N,N',N''-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide | N,N',N''Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide | SCHEMBL3321012 | 1,3,5-B

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Shipped at room temperature. Store at -20°C.

Application

LM22A-4 has been used as a component of dissociation medium for mouse embryonic stem cells (mESC) and human embryonic stem (hESC) aggregates.

Specifications

Synonyme

LM 22A4 | LM22a4 | LM-22A4 | LM22A-4 | N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide | 5GCL3P6AF5 | N,N',N''-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide | N,N',N''Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide | SCHEMBL3321012 | 1,3,5-B

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Small molecule BDNF mimetic displaying neurotrophic activity. Partial agonist at TrkB, activating TrkB signaling. Displaces BDNF (IC 50 = 47 nM) in binding assays.\xa0Prevents neuronal degeneration with equal efficacy to that of BDNF in in vitro models of

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

AGONIST

Namen und Kennungen

• Pubchem Sid: 528765295
• Kanonisches Lächeln: C1=C(C=C(C=C1C(=O)NCCO)C(=O)NCCO)C(=O)NCCO
• IUPAC Name: 1-N,3-N,5-N-tris(2-hydroxyethyl)benzene-1,3,5-tricarboxamide
• InChIKey: RGWJKANXFYJKHN-UHFFFAOYSA-N
• INCHI: 1S/C15H21N3O6/c19-4-1-16-13(22)10-7-11(14(23)17-2-5-20)9-12(8-10)15(24)18-3-6-21/h7-9,19-21H,1-6H2,(H,16,22)(H,17,23)(H,18,24)
• Isomere SMILES: C1=C(C=C(C=C1C(=O)NCCO)C(=O)NCCO)C(=O)NCCO
• Molekulargewicht: 339.34
• Reaxy-Rn: 2398310
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2398310&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Benzene and substituted derivatives
      • Subclass Benzoic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Benzene and substituted derivatives
• Subclass: Benzoic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzamides
• Alternative Parents: N-acylethanolamines Benzoyl derivatives Secondary carboxylic acid amides Primary alcohols Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzamide - Benzoyl - N-acylethanolamine - Carboxamide group - Secondary carboxylic acid amide - Alkanolamine - Carboxylic acid derivative - Alcohol - Organooxygen compound - Organonitrogen compound - Primary alcohol - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic homomonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as benzamides. These are organic compounds containing a carboxamido substituent attached to a benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (nicht menschlich)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Molekulargewicht: 339.340 g/mol
• XLogP3: -2.300
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 9
• Exact Mass: 339.143 Da
• Monoisotopic Mass: 339.143 Da
• Topological Polar Surface Area: 148.000 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 358.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1