LRE1 - Moligand™,≥98% , Inhibitor of adenylyl cyclase 10, CAS No.1252362-53-0, Inhibitor of adenylyl cyclase 10

CAS: 1252362-53-0 Cat. No.: L611587 Summenformel: C₁₂H₁₃ClN₄S Molekulargewicht: 280.78 PubChem CID: 47279808

GRADE & PURITY Moligand™, ≥98%

Synonyms

RU-0204277 | 6-Chloro-N4-cyclopropyl-N4-(thiophen-2-ylmethyl)pyrimidine-2,4-diamine

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Übersicht

LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.

Specifications

Synonyme

RU-0204277 | 6-Chloro-N4-cyclopropyl-N4-(thiophen-2-ylmethyl)pyrimidine-2,4-diamine

Spezifikationen & Reinheit

Moligand™,≥98%

Biochemische und physiologische Mechanismen

LRE1 is a selective allosteric inhibitor of soluble adenylyl cyclase (sAC), a ubiquitously expressed, essential component of cAMP-signaling. In contrast to G-protein-regulated transmembrane adenylyl cyclase, soluble adenylyl cyclase is directly activated

Storage

Protected from light,Store at -20°C,Argon charged

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Inhibitor of adenylyl cyclase 10

Reinheit

≥98%

Namen und Kennungen

• Pubchem Sid: 528765302
• Kanonisches Lächeln: C1CC1N(CC2=CC=CS2)C3=CC(=NC(=N3)N)Cl
• IUPAC Name: 6-chloro-4-N-cyclopropyl-4-N-(thiophen-2-ylmethyl)pyrimidine-2,4-diamine
• InChIKey: PDWZXKSZLRVSEH-UHFFFAOYSA-N
• INCHI: 1S/C12H13ClN4S/c13-10-6-11(16-12(14)15-10)17(8-3-4-8)7-9-2-1-5-18-9/h1-2,5-6,8H,3-4,7H2,(H2,14,15,16)
• Isomere SMILES: C1CC1N(CC2=CC=CS2)C3=CC(=NC(=N3)N)Cl
• PubChem CID: 47279808
• Molekulargewicht: 280.78

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Klasse Organonitrogen compounds
      • Subclass Amines
        • Ebene5 Tertiary amines
          • Ebene6 Tertiary alkylarylamines
            • Ebene7 Dialkylarylamines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Klasse: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Tertiary amines - Tertiary alkylarylamines
• Direct Parent: Dialkylarylamines
• Alternative Parents: Halopyrimidines Aminopyrimidines and derivatives Imidolactams Aryl chlorides Thiophenes Heteroaromatic compounds Azacyclic compounds Primary amines Organochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Dialkylarylamine - Aminopyrimidine - Halopyrimidine - Imidolactam - Pyrimidine - Aryl halide - Aryl chloride - Thiophene - Heteroaromatic compound - Organoheterocyclic compound - Azacycle - Hydrocarbon derivative - Primary amine - Organochloride - Organohalogen compound - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as dialkylarylamines. These are aliphatic aromatic amines in which the amino group is linked to two aliphatic chains and one aromatic group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

ADCY10 Tchem Adenylate cyclase type 10 (1 Activities)

Discover Target: ADCY10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Empfindlichkeit: light sensitive
• Molekulargewicht: 280.780 g/mol
• XLogP3: 3.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 280.055 Da
• Monoisotopic Mass: 280.055 Da
• Topological Polar Surface Area: 83.300 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 289.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1