Lu AE98134 - 10mM in DMSO , CAS No.849000-18-6

CAS: 849000-18-6 Cat. No.: L656882 Summenformel: C₂₁H₂₃N₅O₃S Molekulargewicht: 425.50 PubChem CID: 2044236

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Lu AE98134, an activator of voltage-gated sodium channels , acts as a partly selective Na v 1.1 channels positive modulator. Lu AE98134 also increases the activity of Na v 1.2 and Na v 1.5 channels but not of Na v 1.4, Na v 1.6 and Na v 1.7 channels. Lu AE98134 can be used to analyze pathophysiological functions of the Na v 1.1 channel in various central nervous system diseases, including cognitive restoring in schizophrenia, et al.

In Vitro

Lu AE98134 (30 μM) promotes the current mediated by Nav v 1.1 channel, and it activates Na v 1.5 and to a lesser extent Na v 1.2 but has no effect on Na v 1.4, Na v 1.6 and Na v 1.7 currents in HEK cells expressing Na v 1.1, Na v 1.2, Na v 1.6, Na v 1.5, and Na v 1.7 by step-wise depolarizing voltages using the whole-cell patchclamp configuration. Lu AE98134 (30 μM) increases the excitability of FSINs by decreasing the threshold for action potentials.Intracellular depolarizing current pulses evokes repetitive firing of action potentials at frequencies, additionally, Lu AE98134 increases the excitability since each current pulse generated a higher number of spikes (163 spikes in control; and 230 spikes in Lu AE98134). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The fast spiking inhibitory interneurons (FSINs) from Dlx5/6 +/− animals exhibit abnormal excitability because of a more depolarized spike threshold and broader action potentials. Lu AE98134 (30 μM) increases the excitability of FSINs neurons from normal and Dlx5/6 +/− animals by modulating several parameters characteristic for NaV 1.1 channels. The selective activation of FSINs by Lu AE98134 restores cognitive flexibility in adult Dlx5/6 +/− mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Lu AE98134, an activator of voltage-gated sodium channels , acts as a partly selective Na v 1.1 channels positive modulator. Lu AE98134 also increases the activity of Na v 1.2 and Na v 1.5 channels but not of Na v 1.4, Na v 1.6 and Na v 1.7 channels. Lu A

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

ACTIVATOR

Namen und Kennungen

• Isomere SMILES: CCCCNS(=O)(=O)C1=CC(=C(C=C1)OC)C2=NN=C3N2N=C(C4=CC=CC=C43)C
• PubChem CID: 2044236
• Molekulargewicht: 425.50

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 849000-18-6, the molecular formula is C21H23N5O3S, and the molecular weight is 425.50 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.