LY2334737 - Moligand™,≥98% , CAS No.892128-60-8

CAS: 892128-60-8 Cat. No.: L646572 Summenformel: C₁₇H₂₅F₂N₃O₅ Molekulargewicht: 389.39 PubChem CID: 11646777

GRADE & PURITY Moligand™, ≥98%

Synonyms

HY-13672 | NCGC00378563-01 | 1-(2,2-difluoro-2-deoxy-beta-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one | SCHEMBL595762 | BL98401 | NCGC00378563-02 | JXRHGMJVKRFLOK-UXIGCNINSA-N | DTXSID001025742 | N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

LY2334737 is an nucleoside analog and is an orally active proagent of Gemcitabine. LY2334737 exhibits inhibitory activity against enterovirus A71 (EV-A71) infection . LY2334737 has antiviral and anticancer effects

In Vitro

Five cell lines that express CES2 responded to LY2334737 treatment. LY2334737 is less cytotoxic to a SK-OV-3 CES2 knockdown than parental cells. The drug response of CES2-transfected HCT-116 cells correlated with CES2 expression level. Bystander studies show statistically greater PC-3-GFP growth inhibition by LY2334737 when cells are cocultured with CES2 and not mock transfectants. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oral treatment of xenograft models with 3.2 mg/kg LY2334737 once a day for 21 days shows greater tumor growth inhibition of CES2 transfectant than the mock transfectant . Metronomic LY2334737 administration causes increased blood flow in luciferase-tagged LM2-4 tumor xenografts, and this effect, readily measured using contrast micro-ultrasound, coincided with a relative increase in tumor bioluminescence. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Enterovirus A71 (EV-A71)

Specifications

Synonyme

HY-13672 | NCGC00378563-01 | 1-(2,2-difluoro-2-deoxy-beta-D-ribofuranosyl)-4-(2-propyl-1-oxopentyl)aminopyrimidin-2-one | SCHEMBL595762 | BL98401 | NCGC00378563-02 | JXRHGMJVKRFLOK-UXIGCNINSA-N | DTXSID001025742 | N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5

Spezifikationen & Reinheit

Moligand™,≥98%

Biochemische und physiologische Mechanismen

LY2334737 is a nucleoside analog. LY2334737 exhibits inhibitory activity against enterovirus A71 (EV-A71) infection. LY2334737 possesses antiviral and anticancer effects.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Reinheit

≥98%

Namen und Kennungen

• Kanonisches Lächeln: CCCC(CCC)C(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)CO)O)(F)F
• IUPAC Name: N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]-2-propylpentanamide
• InChIKey: MEOYFIHNRBNEPI-UXIGCNINSA-N
• INCHI: 1S/C17H25F2N3O5/c1-3-5-10(6-4-2)14(25)20-12-7-8-22(16(26)21-12)15-17(18,19)13(24)11(9-23)27-15/h7-8,10-11,13,15,23-24H,3-6,9H2,1-2H3,(H,20,21,25,26)/t11-,13-,15-/m1/s1
• Isomere SMILES: CCCC(CCC)C(=O)NC1=NC(=O)N(C=C1)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F
• Alternative CAS-Nummer: 892128-60-8
• PubChem CID: 11646777
• MeSH-Eintrag: LY2334737
• Molekulargewicht: 389.39

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Klasse Pyrimidine nucleosides
      • Subclass Pyrimidine 2'-deoxyribonucleosides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Klasse: Pyrimidine nucleosides
• Subclass: Pyrimidine 2'-deoxyribonucleosides
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrimidine 2'-deoxyribonucleosides
• Alternative Parents: N-arylamides Pyrimidones Fatty amides Hydropyrimidines Imidolactams Heteroaromatic compounds Oxolanes Secondary alcohols Fluorohydrins Secondary carboxylic acid amides Azacyclic compounds Oxacyclic compounds Organic oxides Primary alcohols Hydrocarbon derivatives Alkyl fluorides Carbonyl compounds Organofluorides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyrimidine 2'-deoxyribonucleoside - N-arylamide - Pyrimidone - Fatty amide - Hydropyrimidine - Fatty acyl - Imidolactam - Pyrimidine - Heteroaromatic compound - Oxolane - Carboxamide group - Fluorohydrin - Halohydrin - Secondary carboxylic acid amide - Secondary alcohol - Carboxylic acid derivative - Oxacycle - Azacycle - Organoheterocyclic compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alkyl fluoride - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Alcohol - Organic nitrogen compound - Carbonyl group - Organooxygen compound - Alkyl halide - Primary alcohol - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as pyrimidine 2'-deoxyribonucleosides. These are compounds consisting of a pyrimidine linked to a ribose which lacks a hydroxyl group at position 2.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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CCRF-CEM (65223 Activities)

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MCF7 (126967 Activities)

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HCT-116 (91556 Activities)

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HeLa (62764 Activities)

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Zugehörige Ziele (nicht menschlich)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

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Mus musculus (284745 Activities)

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L1210 (27553 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Blood (6 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : ≥ 100 mg/mL (256.81 mM)
• Molekulargewicht: 389.400 g/mol
• XLogP3: 1.700
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 389.176 Da
• Monoisotopic Mass: 389.176 Da
• Topological Polar Surface Area: 111.000 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 620.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 892128-60-8, the molecular formula is C17H25F2N3O5, and the molecular weight is 389.39 g/mol. InChIKey MEOYFIHNRBNEPI-UXIGCNINSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.