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M-110 - 10mM in DMSO , CAS No.1395048-49-3
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GRADE & PURITY 10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Why this grade
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC 50 =47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC 50 s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC 50 s of 0.6 to 0.9 μM.
In Vitro
M-110 (0.01-10 μM; 72 hours) inhibiting the growth of DU-145 cells with an IC 50 value of 0.9 μM. M-110 has no activity on normal human peripheral blood mononuclear cells up to 40 μM. M-110 (10 μM; 18 hours) inhibits STAT3 Tyr705 phosphorylation. M-110 inhibits the expression of active STAT3 through inhibition of PIM-3. M-110 also inhibits the proliferation of 22Rv1, PC3, and SW480 cells, with IC50 values of 0.6 to 0.8 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: DU-145 cells Concentration: 0.01, 0.1, 1, 10 μM Incubation Time: 72 hours Result: Inhibiting the growth of DU-145 cells with an IC 50 value of 0.9 μM. Western Blot AnalysisCell Line: DU-145 cells Concentration: 10 μM Incubation Time: 18 hours Result: Reduced the expression of p-STAT3 Tyr705 to 23.5%, compared with untreated cells without affecting the expression of STAT3.
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC 50 =47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC 50 s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC 50 s of
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Names and Identifiers
| WGK Germany | 3 |
|---|---|
| PubChem CID | 136246423 |
| Molecular Weight | 445.94 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
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Look up COA →🔬 Specification Sheet
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View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
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