Magnolol - Moligand™, ≥98%(HPLC) , CAS No.528-43-8

CAS: 528-43-8 Cat. No.: M111378 Summenformel: C₁₈H₁₈O₂ Molekulargewicht: 266.33 Beilstein Registry Number: 6(4)6918 EG-Nummer: 610-903-7

QUALITÄT & REINHEIT Moligand™, ≥98%(HPLC)

Synonyms

NCGC00161609-01 | Ethylene glycol butyl ether | s2321 | STK801955 | Methyl n-dodecanoate | Magnolol,(S) | 5,5'-DI-2-PROPEN-1-YL-(1,1'-BIPHENYL)-2,2'-DIOL | MAGNOLOL [INCI] | Q-100598 | Magnolol, European Pharmacopoeia (EP) Reference Standard | UNII-001E35

Storage

Store at 2-8°C

Shipped In

Wet ice

Übersicht

Bioactive plant component with antifungal, antibacterial and antioxidant effects.Magnolol also demonstrates anti-inflammatory activity by interferring with NF-κB signaling.

Spezifikationen

Synonyme

NCGC00161609-01 | Ethylene glycol butyl ether | s2321 | STK801955 | Methyl n-dodecanoate | Magnolol,(S) | 5,5'-DI-2-PROPEN-1-YL-(1,1'-BIPHENYL)-2,2'-DIOL | MAGNOLOL [INCI] | Q-100598 | Magnolol, European Pharmacopoeia (EP) Reference Standard | UNII-001E35

Spezifikationen & Reinheit

Moligand™, ≥98%(HPLC)

Biochemische und physiologische Mechanismen

Potent antioxidant. Inhibits iNOS expression (IC 50 = 16.8 μM). Anti-inflammatory, antioxidative, antitumor, antimicrobial and apoptotic agent. Induces apoptosis by upregulating p53 and bax expression. Honokiol ( Asc 647 ) isomer.

Storage

Store at 2-8°C

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Reinheit

≥98%(HPLC)

Namen und Kennungen

Pubchem Sid

488184686

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488184686

Kanonisches Lächeln

C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O

IUPAC Name

2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol

InChIKey

VVOAZFWZEDHOOU-UHFFFAOYSA-N

INCHI

1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2

Isomere SMILES

C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O

WGK Deutschland

3

RTECS

DV5105500

UN-Nummer

3077

Molekulargewicht

266.33

Beilstein

6(4)6918

Reaxy-Rn

1982224

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1982224&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biphenyls and derivatives
• Alternative Parents: 1-hydroxy-2-unsubstituted benzenoids Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Biphenyl - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic homomonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
• External Descriptors: Neolignans

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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MGAM Tclin Maltase-glucoamylase (654 Activities)

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ALDH2 Tclin Aldehyde dehydrogenase (509 Activities)

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CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

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PTH1R Tclin Parathyroid hormone receptor (47172 Activities)

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CNR2 Tchem Cannabinoid CB2 receptor (16942 Activities)

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ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

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GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

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MTNR1A Tclin Melatonin receptor 1A (2519 Activities)

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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PARP1 Tclin Poly [ADP-ribose] polymerase-1 (6206 Activities)

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GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

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AGS (1999 Activities)

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CCRF-CEM (65223 Activities)

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HL-60 (67320 Activities)

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K562 (73714 Activities)

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LoVo (4724 Activities)

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MCF7 (126967 Activities)

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NCI-H1975 (4994 Activities)

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MOLT-4 (49676 Activities)

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NCI-H358 (882 Activities)

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OVCAR-3 (48710 Activities)

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PC-3 (62116 Activities)

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Raji (5516 Activities)

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SGC-7901 (2773 Activities)

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SW480 (6023 Activities)

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U-251 (51189 Activities)

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A549 (127892 Activities)

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T47D (39041 Activities)

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NCI-H1299 (3248 Activities)

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HEK293 (82097 Activities)

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HONE1 cell line (118 Activities)

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HepG2 (196354 Activities)

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NCI-H460 (60772 Activities)

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PC-9 (1037 Activities)

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HeLa (62764 Activities)

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MDA-MB-231 (73002 Activities)

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PBMC (10003 Activities)

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MGLL Tchem Monoglyceride lipase (1909 Activities)

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SLC5A7 Tchem High-affinity choline transporter (1462 Activities)

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TNKS Tchem Tankyrase-1 (1241 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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TNKS2 Tchem Tankyrase-2 (1531 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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GPR55 Tclin G-protein coupled receptor 55 (1594 Activities)

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NCI-H1650 (1118 Activities)

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NCI-H441 (233 Activities)

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

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Melatonin receptor 1B (19 Activities)

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Ppard Peroxisome proliferator-activated receptor delta (358 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Faah Anandamide amidohydrolase (3907 Activities)

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Enterococcus (1748 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Shigella flexneri (1836 Activities)

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Micrococcus luteus (7463 Activities)

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Staphylococcus aureus (210822 Activities)

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Staphylococcus epidermidis (22802 Activities)

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Alcaligenes faecalis (37 Activities)

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Escherichia coli (133304 Activities)

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Serratia marcescens (3237 Activities)

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Bacillus subtilis (32866 Activities)

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Enterococcus faecalis (29875 Activities)

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Bacillus cereus (7522 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Mus musculus (284745 Activities)

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Hepatitis B virus (7925 Activities)

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Human immunodeficiency virus 1 (70413 Activities)

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Salmonella enterica (1497 Activities)

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Stenotrophomonas maltophilia (1743 Activities)

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RAW264.7 (28094 Activities)

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Vero (26788 Activities)

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SVR (53 Activities)

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Npsr1 Neuropeptide S receptor (260 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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BCHE Cholinesterase (8742 Activities)

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Danio rerio (3092 Activities)

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Trichophyton mentagrophytes (4846 Activities)

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TGR Thioredoxin glutathione reductase (28579 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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PA Polymerase acidic protein (806 Activities)

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

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FTL Ferritin light chain (43324 Activities)

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NS1 Nonstructural protein 1 (33327 Activities)

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TIM10 Mitochondrial import inner membrane translocase subunit TIM10 (1435 Activities)

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Gabrg2 GABA-A receptor; alpha-1/beta-2/gamma-2 (554 Activities)

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vpr Aberrant vpr protein (14595 Activities)

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SARS-CoV-2 (38078 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Empfindlichkeit: Heat Sensitive
• Siedepunkt (°C): 180 °C/1 mmHg
• Schmelzpunkt (°C): 101 °C
• Molekulargewicht: 266.300 g/mol
• XLogP3: 5.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 266.131 Da
• Monoisotopic Mass: 266.131 Da
• Topological Polar Surface Area: 40.500 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 293.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Häufig gestellte Fragen

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at 2–8 °C. Refrigerated storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 528-43-8, the molecular formula is C18H18O2, and the molecular weight is 266.33 g/mol. InChIKey VVOAZFWZEDHOOU-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.