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Manitimus - 10mM in DMSO , CAS No.202057-76-9
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Why this grade
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Manitimus is an inhibitor of dehydroorotate dehydrogenase, and a potent immunosuppressive agent.
In Vivo
In the Manitimus-treated rats, there is a dose-related, differential effect: mean survival is 15.7 days in group 4 (Manitimus 5 mg/kg), 19.1 days in group 5 (Manitimus 10 mg/kg) and 25.4 days in group 6 (Manitimus 20 mg/kg) . Manitimus (15 mg/kg, p.o.) results in a significant decrease in neointimal area and percentage of stenosis versus the control rats, and diminishes the effect that CMV infection results in a significant increase in intimal and medial cross-sectional area and medial wall thickness of the vein grafts. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal administration
The whole experiment consists of a total of four experimental groups (n = 10 animals/group) which all undergo surgery. Furthermore, rats are either infected with CMV, treated with Manitimus\nor both. A control group only receive the Manitimus solvent (1 mL of a 1% carboxymethylcellulose solution in water). Infection is established by inoculating rats intraperitoneally with 1.25×10 6 plaque-forming units of homogenized salivary gland-derived rat CMV immediately after surgery. aladdin has not independently confirmed the accuracy of these methods. They are for reference only.
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Manitimus is an inhibitor of dehydroorotate dehydrogenase, and a potent immunosuppressive agent.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers
| Isomeric SMILES | C#CCC/C(=C(\C#N)/C(=O)NC1=CC=C(C=C1)C(F)(F)F)/O |
|---|---|
| Alternate CAS | 202057-76-9,185915-33-7 |
| PubChem CID | 54686843 |
| MeSH Entry Terms | 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide;2-cyano-3-hydroxy-N-(4--(trifluoromethyl)phenyl)-2-hepten-6-ynoic acid;FK 778;FK-778;FK778;HMR 1715;HMR-1715;malononitrilamide 715;malononitrilamide-715;MNA 715;MNA-715;MNA-X 920715;X 9207 |
| Molecular Weight | 308.26 |
Documentation
📋 Safety Data Sheet (SDS)
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Download SDS →✅ Certificate of Analysis (COA)
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