MAPK-IN-2 - ≥98% , CAS No.M1426099

CAS: M1426099 Cat. No.: M1426099 Summenformel: C₂₀H₁₁Cl₂N₃O Molekulargewicht: 380.23

GRADE & PURITY ≥98%

Storage

Store at 2-8°C

Shipped In

Wet ice

Übersicht

MAPK-IN-2 (compound 3h) is a potent MAPK inhibitor with antineoplastic activity. MAPK-IN-2 inhibits cancer cell proliferation among serval cancer cell lines, and suppresses MAPK pathway with potant efficacy ( EGFR WT IC 50 =281 nM, c-MET IC 50 =205 nM, B-RAF WT IC 50 =112 nM, and CDK4/6 IC 50 =95 and 184 nM, respectively). MAPK-IN-2 even shows a remarkable potency against mutated EGFR and B-RAF ( EGFR T790M IC 50 =69 nM and B-RAF V600E IC 50 =83 nM).

Specifications

Spezifikationen & Reinheit

≥98%

Storage

Store at 2-8°C

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥98%

Namen und Kennungen

• Molekulargewicht: 380.23