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Masofaniten - ≥98% , CAS No.2416716-62-4
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Masofaniten (Androgen receptor-IN-2) is a potent and orally active androgen receptor inhibitor. Masofaniten has antitumor activity against prostate cancer
In Vitro
Masofaniten (compound A109, androgen-induced PSA-Luciferase assay) inhibits androgen binding to androgen receptor with an IC 50 of 535 nM. Masofaniten inhibits cell proliferation in LNCaP and LNCaP95 cells (IC 50 : 0.44 μM, 3.78 μM respectively). Masofaniten shows a metabolic stability in liver microsome with a t 1/2 of more than 120 min, and in hepatocytes with a t 1/2 of more than 360 min. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Masofaniten (compound A109) (60 mg/kg, p.o.) induces partial regressions of tumor growth in NCG mice bearing LNCaP tumors . Masofaniten (5 mg/kg, p.o., single dose, in male CD-1 mice) shows a t 1/2 of 8.1 h, C max of 2673.3 ng/mL, F (%) of 33.6 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: LNCaP Xenografts Model Dosage: 60 mg/kg Administration: Oral administration (p.o.) Result: Inhibited tumor growth no obvious drug related toxicity (bodyweight change).
Form:Solid
IC50& Target:Androgen receptor
Specifications
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
Masofaniten (Androgen receptor-IN-2) is a potent and orally active androgen receptor inhibitor. Masofaniten has antitumor activity against prostate cancer.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥98%
Names and Identifiers
| Isomeric SMILES | CC(C)(C1=CC=C(C=C1)OCC2=NC(=NC=C2)NS(=O)(=O)C)C3=CC(=C(C(=C3)Cl)OCCCl)C#N |
|---|---|
| PubChem CID | 146484310 |
| Molecular Weight | 535.44 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 50 mg/mL (93.38 mM; Need ultrasonic and warming) |
|---|
Solution Calculators
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