MEA - Moligand™ , CAS No.142-58-5

CAS: 142-58-5 Cat. No.: M611775 Summenformel: C₁₆H₃₃NO₂ Molekulargewicht: 271.44 EG-Nummer: 205-546-5 PubChem CID: 8890

QUALITÄT & REINHEIT Moligand™

Synonyms

142-58-5|N-(2-HYDROXYETHYL)TETRADECANAMIDE|N-(2-Hydroxyethyl)myristamide|Myristic monoethanolamide|Myristamide MEA|N-myristoylethanolamine|Tetradecanamide, N-(2-hydroxyethyl)-|myristoyl ethanolamide|Comperlan MM|Myristoyl-EA|Loramine MY 228|Myristoyl-etha

Storage

Room temperature

Spezifikationen

Synonyme

142-58-5 | N-(2-HYDROXYETHYL)TETRADECANAMIDE | N-(2-Hydroxyethyl)myristamide | Myristic monoethanolamide | Myristamide MEA | N-myristoylethanolamine | Tetradecanamide, N-(2-hydroxyethyl)- | myristoyl ethanolamide | Comperlan MM | Myristoyl-EA | Loramine MY 228 | Myristoyl-etha

Spezifikationen & Reinheit

Moligand™

Storage

Room temperature

Note

Moligand™

Namen und Kennungen

Kanonisches Lächeln

CCCCCCCCCCCCCC(=O)NCCO

IUPAC Name

N-(2-hydroxyethyl)tetradecanamide

InChIKey

JHIXEZNTXMFXEK-UHFFFAOYSA-N

INCHI

1S/C16H33NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-16(19)17-14-15-18/h18H,2-15H2,1H3,(H,17,19)

Isomere SMILES

CCCCCCCCCCCCCC(=O)NCCO

PubChem CID

8890

Molekulargewicht

271.44

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Klasse Organonitrogen compounds
      • Subclass Amines
        • Ebene5 Alkanolamines
          • Ebene6 1,2-aminoalcohols
            • Ebene7 N-acylethanolamines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Klasse: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Alkanolamines - 1,2-aminoalcohols
• Direct Parent: N-acylethanolamines
• Alternative Parents: N-acyl amines Secondary carboxylic acid amides Primary alcohols Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: N-acylethanolamine - Fatty amide - N-acyl-amine - Fatty acyl - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Alcohol - Organooxygen compound - Primary alcohol - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Aliphatic acyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as n-acylethanolamines. These are compounds containing an N-acyethanolamine moiety, which is characterized by an acyl group is linked to the nitrogen atom of ethanolamine.
• External Descriptors: N-acyl ethanolamines (endocannabinoids)

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemische und physikalische Eigenschaften

• Molekulargewicht: 271.440 g/mol
• XLogP3: 5.100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 14
• Exact Mass: 271.251 Da
• Monoisotopic Mass: 271.251 Da
• Topological Polar Surface Area: 49.300 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 195.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Application Protocols

No tested application protocols are supplied for this SKU. As a general starting point for small-molecule screening compounds:

• Stock preparation: Dissolve in anhydrous DMSO to a convenient concentration (e.g., 10–50 mM), vortex and, if needed, sonicate briefly. Filter or centrifuge to clarify.
• Working solutions: Dilute into assay buffer to the desired final concentration, keeping DMSO ≤1% v/v unless your assay tolerates more. Confirm absence of precipitate.
• Storage of working stocks: Keep on ice and use the same day; assess stability by LC–MS if solutions are to be stored.
• Analytical check: Run a quick LC–MS before critical assays to confirm integrity and concentration.

Any item-specific protocols (WB, IHC, IF, FC, enzymology conditions, etc.) are: Not specified for this item; refer to CoA/Spec Sheet.

Biological Roles

The biological roles of this item cannot be described without a confirmed structure. MEA is an acronym used for distinct chemotypes in the literature, each with different biochemical properties.

General guidance for Moligand™ screening compounds

• Treat as a chemical probe candidate whose biological activity, target engagement, and ADME properties are unknown until experimentally determined.
• Prior to cellular assays, assess basic liabilities: colloidal aggregation (e.g., detergent counterscreens), redox cycling, fluorescence interference, and nonspecific reactivity.
• Establish compound stability in assay media (buffer components, pH, presence of reductants/oxidants) via LC–MS time-course.
• If proceeding to cell-based work, profile permeability (e.g., PAMPA/MDCK), solubility, and nonspecific binding (HSA/MDE). These are assay design considerations rather than claims about this product.

No medical or clinical claims are made. This product is for research use only, as stated by the manufacturer.

Buffer Applications

Not typically applicable. This product is a small-molecule screening compound rather than a buffering reagent. No pKa or buffering capacity information is provided in the listing.

• If the compound contains ionizable groups (to be confirmed from its CoA), any apparent pH effects in assays should be considered confounders rather than intentional buffering.
• Select established biological buffers (e.g., phosphate, HEPES, MOPS, Tris) to control pH, and maintain the compound as a solute at concentrations unlikely to perturb buffer capacity.

All buffer-related specifications for this item are: Not specified for this item; refer to CoA/Spec Sheet.

Green Alternatives

Without a confirmed chemical structure, solvent and process greenness must be addressed at the workflow level rather than the molecule level.

Greener handling strategies (general)

• Prefer aqueous buffers with minimal DMSO where compatible with solubility and assay performance; target ≤0.5–1% DMSO in final assay wells.
• Use lower-toxicity, higher-biodegradability solvents for cleaning and sample prep when feasible (e.g., ethanol, isopropanol) instead of chlorinated solvents.
• Miniaturize assays (e.g., 384/1536-well formats) to reduce solvent consumption and waste.
• Implement DoE-driven solubility optimization to avoid unnecessary co-solvents.

Illustrative solvent comparison (general)

• DMSO vs ethanol: DMSO offers broader solubility; ethanol is greener and evaporates readily but may not dissolve polar/heteroatom-rich chemotypes.
• Acetonitrile vs methanol (for LC): MeCN provides lower backpressure and strong elution; MeOH is greener but may lengthen runs; consider water-rich gradients.

Waste and safety

• Segregate halogenated from non-halogenated waste; avoid peroxidable ethers unless the structure requires them for specific analytics.

Given the absence of compound-specific hazards in this listing, always refer to the SDS and CoA to refine green choices consistent with the actual chemotype.

Pharmaceutical Uses

No excipient or pharmacopeial status is provided for this item. As a Moligand™ library compound, it is intended for research screening and discovery workflows, not for formulation development or therapeutic use.

• Regulatory status: Not specified for this item; refer to CoA/Spec Sheet. Not intended for human or veterinary use.
• Potential roles in R&D (general): reference standard for analytical methods, exploratory hit/probe in medicinal chemistry once identity is confirmed.

Do not incorporate into any clinical, diagnostic, or GMP process. Research use only.

Physical Properties

Item-specific physical constants are not provided in this listing and should be taken from the CoA or SDS supplied for the lot you receive.

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Melting/Freezing point: Not specified for this item; refer to CoA/Spec Sheet.
• Boiling point: Not specified for this item; refer to CoA/Spec Sheet.
• Density: Not specified for this item; refer to CoA/Spec Sheet.
• Refractive index: Not specified for this item; refer to CoA/Spec Sheet.
• Solubility: Not specified for this item; refer to CoA/Spec Sheet. (General screening practice: evaluate DMSO and aqueous buffer tolerance empirically.)
• logP/logD: Not specified for this item; refer to CoA/Spec Sheet.
• pKa: Not specified for this item; refer to CoA/Spec Sheet.
• UV–Vis profile / LC-UV cutoff: Not specified for this item; refer to CoA/Spec Sheet.

Practical notes (general)

• For library compounds of uncertain ionization state, begin with a small-scale solubility screen in anhydrous DMSO (5–20 mM), then dilute into assay buffer with 0.1–1% final DMSO.
• If volatile or odorous, handle in a ventilated hood and minimize open-vial time; if hygroscopic, cap promptly and consider desiccation.
• For HTS/medchem workflows, determine exact concentration by UV (if chromophore known) or quantitative NMR/LC–MS with an internal standard.

Quality and Grades

• Grade/Purity designation: Moligand™ (research use only)

What Moligand™ signifies (general description)

• A curated small-molecule/ligand collection intended for screening, target identification, and hit-finding workflows.
• Emphasis is typically placed on traceable sourcing, identity verification, and screening-suitable formats. The exact QC panel (e.g., purity method, acceptance criteria, residual solvents, salt form) is batch-specific.

Item-specific notes

• Purity, salt/solvate state, water content, and stabilizers: Not specified for this item; refer to CoA/Spec Sheet.
• UV trace/LC method and detection wavelength: Not specified for this item; refer to CoA/Spec Sheet.
• Packaging may be vialed or plate-ready depending on SKU/quantity; confirm format and fill mass/concentration on the label/CoA.

Best practices

• Record lot number and retain CoA with your ELN entry to ensure traceability of screening results.
• If your workflow requires orthogonal QC (qNMR, HRMS, Karl Fischer), perform upon receipt and document against your internal acceptance criteria.
• For compounds prone to degradation (e.g., base/oxidation-sensitive chemotypes), consider aliquoting under inert atmosphere; stability guidance should be taken from the lot-specific documents.

Reaction and Applications

This product is positioned as a Moligand™ small-molecule library member rather than a preparative reagent; therefore, its primary applications are in discovery and screening rather than as a stoichiometric reactant.

Typical research uses (general for library compounds)

• High-throughput screening (HTS) and fragment/ligand discovery against enzymatic or receptor targets.
• Target deconvolution and chemoproteomic pull-downs once suitable handles or tags are introduced.
• Structure–activity relationship (SAR) expansion following initial hit identification; MEA can serve as a reference material for analytical method development and as a seed compound for analog design.

Practical tips

• Verify identity and purity by LC–MS prior to screening; precipitates or secondary peaks can confound assay readouts.
• Prepare fresh DMSO stocks and minimize freeze–thaw cycles to preserve integrity.
• If covalent reactivity is suspected from the structure (to be confirmed from the CoA), incorporate counterscreens for thiol- or amine-reactive PAINS behavior and run GSH trapping assays as needed.

Note: Because the exact functional groups are not specified here, do not plan named reactions or specific derivatizations until you have the definitive structure from the CoA/SDS.

Reaction Conditions

Not applicable without a confirmed structure. No item-specific reactivity profile, catalysts, or condition ranges are provided.

General best practices for handling unknown/unspecified small molecules in experimentation

• Conduct a small-scale stability screen in common solvents (DMSO, acetonitrile, methanol, buffer) at ambient temperature and at 37 °C, monitoring by LC–MS to identify degradation liabilities.
• If the compound is to be derivatized post-reception (after structure confirmation), optimize conditions using micro-scale reactions and orthogonal analytics to preserve sample inventory.

All reaction condition specifics for this product are: Not specified for this item; refer to CoA/Spec Sheet.

Safety and Handling

GHS classification and specific hazard statements are not provided here; consult the product SDS for authoritative guidance for your lot.

• Signal word: Not specified for this item; refer to SDS.
• GHS hazard statements/pictograms: Not specified for this item; refer to SDS.

General laboratory precautions for small-molecule libraries

• Work in a chemical fume hood; avoid inhalation and skin/eye contact. Use appropriate PPE: lab coat, safety glasses, and chemically resistant gloves.
• Unknown or multifunctional amine/thiol/alkoxy-containing compounds may be irritants or sensitizers; adopt conservative handling.
• Avoid incompatible reagents until identity is confirmed; in general, keep away from strong oxidizers, strong acids/bases, and sources of ignition.
• If dusty or volatile, minimize aerosol/vapor generation.

First-aid overview (general)

• Skin/eye contact: Immediately flush with water for ≥15 minutes; remove contaminated clothing.
• Inhalation: Move to fresh air; seek medical attention if symptoms persist.
• Ingestion: Rinse mouth; do not induce vomiting unless directed by medical personnel.

Spill and waste

• Contain with inert absorbent, collect in compatible waste container, and dispose per institutional and local regulations.

Always defer to the official SDS for definitive hazard and response information.

Solvent Selection

Because definitive structural information for MEA (SKU M611775) is not provided in this listing, solvent selection should begin with broadly compatible screening solvents and be refined empirically.

General approach

• Primary stock solvent: Anhydrous DMSO is the default for diverse library members; prepare 10–50 mM stocks as solubility permits.
• Aqueous compatibility: Perform a mini solubility test by diluting DMSO stocks 1:100 into assay buffer (final 0.5–1% DMSO) while observing for precipitation.
• Alternative solvents: DMF or acetonitrile for LC/MS sample prep; ethanol or isopropanol for intermediate polarity analytes where DMSO is undesirable.
• pH adjustment: If the compound contains a basic or acidic functionality (to be confirmed from CoA), modest pH adjustment of aqueous media may aid solubility. Verify chemical stability before basification or acidification.

Comparison guidance (general)

• DMSO: Broadest solubilizing power; hygroscopic and can affect assays at >1–2% v/v.
• DMF/MeCN: LC-friendly; lower viscosity than DMSO but can extract plastics; verify bioassay tolerance.
• EtOH/IPA: Volatile, convenient for rapid drying; lower solvency for highly lipophilic or strongly hydrogen-bonding analytes.

Note: Do not assume water solubility or volatility without structural confirmation. Always filter or centrifuge working solutions to remove undissolved particulates before assays.

Storage and Reconstitution

• Storage conditions (as provided): Room temperature.
• Shipped in: Not specified for this item; refer to CoA/Spec Sheet.
• Appearance: Not specified for this item; refer to CoA/Spec Sheet.

General guidance for Moligand™ small-molecule vials/plates

• Upon receipt: Inspect packaging, record lot and receive date. If provided as a dry solid, store tightly capped, protected from light and moisture. If provided as a DMSO solution, keep sealed to minimize evaporation and water uptake.
• Aliquoting: For hygroscopic or air-sensitive compounds, aliquot under dry nitrogen/argon into crimped or screw-cap vials with PTFE-lined septa to reduce headspace and moisture ingress.
• Reconstitution: Start with anhydrous DMSO to prepare a concentrated stock (e.g., 10–50 mM). If necessary, add co-solvent (MeCN/EtOH) or gentle warming (≤40 °C) to aid dissolution. Do not exceed conditions that risk decomposition; verify by LC–MS.
• Freeze–thaw: Minimize cycles. If long-term storage is needed, prepare single-use aliquots and store according to stability data on the CoA/SDS (RT as indicated; if uncertainty remains, 2–8 °C, desiccated, is a conservative interim measure pending confirmation).

All item-specific stability, solubility, and shelf-life details are: Not specified for this item; refer to CoA/Spec Sheet.

Structure and Identity

A small-molecule entry from the Moligand screening collection. The listing does not provide unambiguous structural identifiers beyond CAS; MEA is an acronym used for multiple chemotypes in the literature.

• SKU: M611775
• Product name: MEA (Moligand collection member)
• CAS: 142-58-5 (verify against CoA/SDS before use)
• PubChem CID: 8890 (verify mapping to CAS before use)
• InChIKey: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.

Structural features

• The common abbreviation “MEA” is used in the literature for more than one compound class (e.g., ethanolamines, 2-mercaptoethylamines, methoxyethylamines). Because the present listing lacks a definitive structure line, do not assume a specific functional group or scaffold without consulting the item’s CoA/SDS.

Identity confirmation guidance (general best practice)

• Acquire or consult the supplied CoA and SDS for definitive identifiers (IUPAC name, InChIKey, exact mass).
• Perform orthogonal confirmation if needed for screening campaigns: LC–MS (ESI±), 1H/13C NMR, and HRMS.
• Cross-check catalog barcode/lot with internal LIMs to ensure the plate or vial matches the intended chemotype.

Note: All item-specific structure fields not explicitly listed above are “Not specified for this item; refer to CoA/Spec Sheet.”

Synthetic Utility

Preparative synthetic guidance cannot be provided without a confirmed structure. The listing lacks functional group information necessary to recommend transformations or retrosynthetic pathways.

General considerations if derivatization is planned after structure confirmation

• Map reactive handles (e.g., amines, alcohols, thiols, aryl halides) and choose chemoselective transformations (amide coupling, alkylation, click chemistry, cross-coupling) accordingly.
• For SAR campaigns, design vectors that minimally perturb physicochemical properties (cLogP, TPSA, pKa) and maintain synthetic tractability.
• Establish robust analytical criteria (LC–MS purity, qNMR content) for intermediates and final analogs to ensure data integrity in bioassays.

Until the exact chemotype is verified from the CoA/SDS, refrain from planning or reporting specific named reactions on this SKU.

Target Specificity

No target specificity information is provided for this item. As a Moligand™ screening compound, it has no validated biological target in this catalog entry.

• Target/epitope/clone/isotype data: Not applicable (this is not an antibody or biologic).
• Any claims of selectivity or potency must stem from your own experimental data or from documentation accompanying the exact structure of the lot supplied.

All target-related fields are: Not specified for this item; refer to CoA/Spec Sheet.

Häufig gestellte Fragen

How should this product be stored?

Store at room temperature.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 142-58-5, the molecular formula is C16H33NO2, and the molecular weight is 271.44 g/mol. InChIKey JHIXEZNTXMFXEK-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.