Melphalan(L-PAM) - Moligand™, ≥90% , DNA inhibitor, CAS No.148-82-3, DNA inhibitor

Name: Melphalan(L-PAM) - Moligand™, ≥90% , DNA inhibitor, CAS No.148-82-3, DNA inhibitor
SKU: M191037
Availability: InStock

CAS: 148-82-3 Cat. No.: M191037 Summenformel: C₁₃H₁₈Cl₂N₂O₂ Molekulargewicht: 305.20 EG-Nummer: 205-726-3

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Melphalan(L-PAM) - Moligand™, ≥90% CAS No(148-82-3) by Aladdin Scientific

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GRADE & PURITY Moligand™ ? ≥90%

Synonyms

Storage

Protected from light,Room temperature

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Übersicht Specifications Produkteigenschaften Namen und Kennungen Documentation Advanced Data Taxonomic Classification 3D-Struktur Zugehörige Ziele (menschlich) Zugehörige Ziele (nicht menschlich) Wirkungsmechanismen Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm) Chemische und physikalische Eigenschaften FAQs und Artikel Citations of This Product Referenzen Lösungsrechner Bewertungen

🧪

Why this grade

Moligand™, ≥90% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Protected from light,Room temperature Ships FedEx DG Service Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Übersicht

Melphalan is an effective DNA alkylating agent, with potent antitumor activity.

Melphalan has been used as a drug along with HDAC-inhibitor JNJ-26481585 to treat multiple myeloma (MM) in cell lines and as a chemotherapeutic agent for breast cancer cell line.

Specifications

Synonyme

Spezifikationen & Reinheit

Moligand™, ≥90%

Biochemische und physiologische Mechanismen

Alkylating agent. Phenylamine derivative of mechorethamine. Attaches an alkyl group to the guanine base of DNA at the number 7 nitrogen atom of the imidazole ring. Active in vivo .

Storage

Protected from light,Room temperature

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Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

DNA inhibitor

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Reinheit

≥90%

Produkteigenschaften

ALogP	-0.5

Namen und Kennungen

Pubchem Sid	488189913
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488189913
Kanonisches Lächeln	C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl
IUPAC Name	(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
InChIKey	SGDBTWWWUNNDEQ-LBPRGKRZSA-N
INCHI	1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1
Isomere SMILES	C1=CC(=CC=C1C[C@@H](C(=O)O)N)N(CCCl)CCCl
UN-Nummer	2811
Verpackungsgruppe	I
Molekulargewicht	305.20
Reaxy-Rn	1485409
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1485409&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Klasse Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Ebene5 Amino acids and derivatives
        Ebene6 Alpha amino acids and derivatives
        Ebene7 Phenylalanine and derivatives

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Klasse	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent	Phenylalanine and derivatives
Alternative Parents	Phenylpropanoic acids Amphetamines and derivatives L-alpha-amino acids Aniline and substituted anilines Dialkylarylamines Nitrogen mustard compounds Aralkylamines Amino acids Monocarboxylic acids and derivatives Carboxylic acids Hydrocarbon derivatives Organic oxides Carbonyl compounds Alkyl chlorides Organochlorides Organopnictogen compounds Monoalkylamines
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Phenylalanine or derivatives - 3-phenylpropanoic-acid - Alpha-amino acid - Amphetamine or derivatives - L-alpha-amino acid - Nitrogen mustard - Tertiary aliphatic/aromatic amine - Aniline or substituted anilines - Dialkylarylamine - Aralkylamine - Monocyclic benzene moiety - Benzenoid - Amino acid - Tertiary amine - Carboxylic acid - Monocarboxylic acid or derivatives - Organic oxide - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Hydrocarbon derivative - Organic nitrogen compound - Primary aliphatic amine - Primary amine - Carbonyl group - Organopnictogen compound - Alkyl halide - Amine - Organic oxygen compound - Alkyl chloride - Aromatic homomonocyclic compound
Beschreibung	This compound belongs to the class of organic compounds known as phenylalanine and derivatives. These are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
External Descriptors	organochlorine compound - non-proteinogenic L-alpha-amino acid - L-phenylalanine derivative - nitrogen mustard
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D-Struktur

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PDE5A Tclin Phosphodiesterase 5A (5113 Activities)

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EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

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F2 Tclin Thrombin (11687 Activities)

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CA2 Tclin Carbonic anhydrase II (17698 Activities)

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ESR1 Tclin Estrogen receptor alpha (17718 Activities)

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HMGCR Tclin HMG-CoA reductase (2475 Activities)

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NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

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INSR Tclin Insulin receptor (5558 Activities)

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PGR Tclin Progesterone receptor (8562 Activities)

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ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

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ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)

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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

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AR Tclin Androgen Receptor (11781 Activities)

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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VDR Tclin Vitamin D receptor (26531 Activities)

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ACE Tclin Angiotensin-converting enzyme (1423 Activities)

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DRD2 Tclin Dopamine D2 receptor (23596 Activities)

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MAOA Tclin Monoamine oxidase A (11911 Activities)

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CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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DRD4 Tchem Dopamine D4 receptor (7907 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

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HRH2 Tclin Histamine H2 receptor (5428 Activities)

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ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)

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MAOB Tclin Monoamine oxidase B (8835 Activities)

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HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)

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HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)

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ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

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CALCR Tclin Calcitonin receptor (2215 Activities)

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SLC6A4 Tclin Serotonin transporter (12625 Activities)

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

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PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

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HRH1 Tclin Histamine H1 receptor (7573 Activities)

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ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

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AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)

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OPRD1 Tclin Delta opioid receptor (15096 Activities)

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OPRK1 Tclin Kappa opioid receptor (16155 Activities)

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SLC6A3 Tclin Dopamine transporter (10535 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 Activities)

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PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

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ESR2 Tclin Estrogen receptor beta (9272 Activities)

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Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mc4r Melanocortin receptor 4 (1205 Activities)

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Ltc4s Leukotriene C4 synthase (1 Activities)

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Sigmar1 Sigma opioid receptor (160 Activities)

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Npy1r Neuropeptide Y receptor type 1 (8 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cckar Cholecystokinin A receptor (90 Activities)

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Ppard Peroxisome proliferator-activated receptor delta (358 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Pneumocystis carinii (749 Activities)

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Leishmania infantum (5912 Activities)

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Trypanosoma brucei (78846 Activities)

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Trypanosoma brucei brucei (13300 Activities)

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Entamoeba histolytica (2676 Activities)

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Cryptosporidium parvum (1150 Activities)

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Plasmodium falciparum (966862 Activities)

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Leishmania amazonensis (3813 Activities)

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Leishmania donovani (89745 Activities)

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Leishmania major (2877 Activities)

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Leishmania mexicana (936 Activities)

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Trypanosoma cruzi (99888 Activities)

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Trichomonas vaginalis (2376 Activities)

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Toxoplasma gondii (4585 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Trypanosoma brucei rhodesiense (7991 Activities)

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B16 (5829 Activities)

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CHO (4503 Activities)

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FM3A (1296 Activities)

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L1210 (27553 Activities)

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L1210/LPAM (20 Activities)

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P388 (20296 Activities)

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W256 (236 Activities)

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C6 (2371 Activities)

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Ehrlich (1318 Activities)

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RG2 (196 Activities)

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Salmon testes DNA (254 Activities)

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B16-F10 (4610 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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TGR Thioredoxin glutathione reductase (28579 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

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ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

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Glra2 Glycine receptor (1745 Activities)

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MC3T3-E1 (421 Activities)

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SARS-CoV-2 (38078 Activities)

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Wirkungsmechanismen

Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

20 results found

Lot Number	Certificate Type	Datum	Artikel
H2607638	Certificate of Analysis	Jul 24, 2026	M191037
H2607631	Certificate of Analysis	Jul 24, 2026	M191037
H2607612	Certificate of Analysis	Jul 24, 2026	M191037
I2511785	Certificate of Analysis	Jul 11, 2025	M191037
I2503546	Certificate of Analysis	Jul 11, 2025	M191037
I2503545	Certificate of Analysis	Jul 11, 2025	M191037
C1906056	Certificate of Analysis	Oct 12, 2024	M191037
I2118376	Certificate of Analysis	Jul 04, 2024	M191037
F2520081	Certificate of Analysis	Nov 23, 2022	M191037
B2303024	Certificate of Analysis	Nov 23, 2022	M191037
B2303008	Certificate of Analysis	Nov 23, 2022	M191037
B23021170	Certificate of Analysis	Nov 23, 2022	M191037
B23021168	Certificate of Analysis	Nov 23, 2022	M191037
B23021165	Certificate of Analysis	Nov 23, 2022	M191037
B23021140	Certificate of Analysis	Nov 23, 2022	M191037
H2205595	Certificate of Analysis	Jun 18, 2022	M191037
H2205596	Certificate of Analysis	Jun 18, 2022	M191037
A2214609	Certificate of Analysis	Dec 10, 2021	M191037
A2214611	Certificate of Analysis	Dec 10, 2021	M191037
A2214610	Certificate of Analysis	Dec 10, 2021	M191037

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Chemische und physikalische Eigenschaften

Empfindlichkeit	Light sensitive
Molekulargewicht	305.200 g/mol
XLogP3	-0.500
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	8
Exact Mass	304.075 Da
Monoisotopic Mass	304.075 Da
Topological Polar Surface Area	66.600 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	265.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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DNA Damage and Repair

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inhibitor DNA

Citations of This Product

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Referenzen

1. Guoqing Wang, Kai Wu, Zongliang Zhang, Yongdong Chen, Yanfang Li, Xiaoshuang Jiang, Licong Liang, Yiliu Yang, Hongsong Fan, Jing Sun, Aiping Tong, Fang Lu. (2025) Injectable hydrogel-mediated co-delivery of oncolytic adenovirus and melphalan for retinoblastoma control and vision preservation. Acta Pharmaceutica Sinica B, [PMID:41477337] [10.1016/j.apsb.2025.09.030]
2. Muchao Chen, Yi Yu, Jiaying Hu, Yi-Chi Wang, Dongxu Zhao, Zhaoxin Ji, Lin Xu, Qiang Zhang, Baoye Ma, Yi Liu, Caifang Ni, Lin Gu, Youyong Li, Zhuang Liu, Yang Yang, Qian Chen. (2025) Ultrasound-driven in situ self-assembly of drug hydrogel for enhanced hepatic artery infusion chemotherapy. Materials Today, [PMID:] [10.1016/j.mattod.2025.12.006]
3. Xi Weizhe, Liu Fenfang, Zhong Guangen, Chen Fen, Xie Yin, Lai Meilian, He Qiting, Lu Yiqing, Zhang Jiping, Chen Ying, Meng Luo, Yang Lu. (2025) Therapeutic effects of Melittin acupoint injection on rheumatoid arthritis through autophagy activation and PI3K/AKT/mTOR pathway inhibition. Quantitative Imaging in Medicine and Surgery, 16 (1): (18). [PMID:41521996] [10.21037/qims-2025-540]
4. Wang Song, Ma Rumeng. (2026) Coating on PET fabric by the polyacrylate containing aluminum diethylphosphinate and phytate salt synergistic flame retardant. POLYMER BULLETIN, 83 (5): (215). [PMID:] [10.1007/s00289-026-06283-y]
5. Siyu Shuai, Zhaoxin Ji, Qiang Zhang, Yu Miao, Baoye Ma, Jingjing Shen, Haibin Zhao, Yuan Fang, Zhuyu Hou, Muchao Chen, Xianglei Wu, Qian Chen, Yang Yang. (2026) Self-assembled melphalan hydrogel with nitric oxide delivery for synergistic chemoimmunotherapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:42537370] [10.1016/j.jcis.2026.141243]

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Controlled-release & nanoparticle carrier4

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Melphalan(L-PAM) - Moligand™, ≥90% , DNA inhibitor, CAS No.148-82-3, DNA inhibitor

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