Memantine HCl - 10mM in DMSO , Glutamate [NMDA] receptor negative allosteric modulator, CAS No.41100-52-1, Glutamate [NMDA] receptor negative allosteric modulator

CAS: 41100-52-1 Cat. No.: M409221 Molecular Weight: 215.76 EC Number: 255-219-6

GRADE & PURITY 10mM in DMSO

Synonyms

3,​5-​dimethyl-​tricyclo[3.3.1.13,​7]​decan-​1-​amine,hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Memantine HCl Memantine HCl is an antagonist of NMDAR . It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥100%

Specifications

Synonyms

3, ​5-​dimethyl-​tricyclo[3.3.1.13, ​7]​decan-​1-​amine, hydrochloride (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

NEGATIVE ALLOSTERIC MODULATOR

Mechanism of action

Glutamate [NMDA] receptor negative allosteric modulator

Names and Identifiers

• Isomeric SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
• WGK Germany: 3
• Molecular Weight: 215.76
• Reaxy-Rn: 6573843
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6573843&ln=

Chemical and Physical Properties

• Melt Point(°C): 292°C

References

1. Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang, Daoqing Fan.  (2023)  Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection.  Biosensors-Basel,  13  (4): (489).  [PMID:37185564] [10.3390/bios13040489]

2. Fangfang Shen, Dingqiang Lu, Xiuquan Ling, Xinxian Wang, Tongqi Liu, Tianhua Huang, Kefei He.  (2016)  Thermodynamic analysis and calculation of solubility of Memantine hydrochloride in ethanol plus (acetonitrile, water, ethyl acetate) binary solvent mixtures.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2016.12.051]

3. Gong Chen, Panyang Gu, Wenfang Wu, Yuan Yin, Liangyu Pan, Shu Huang, Wei Lin, Meichun Deng.  (2024)  SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39476923] [10.1016/j.ijbiomac.2024.136767]