≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 8 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Description
PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visitAladdin.com/safc-pharmagrade.MES is a biological buffer often referred to as a “Good′s” buffer. The pKa of MES is 5.96 which makes MES an ideal candidate for medias and protein based buffer formulations to maintain a stable environment in solution. MES is considered to be non-toxic to culture cell lines, highly water soluble and provides high-solution clarity.MES is used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream), and diagnostic reagents. MES based buffers are used in purification bioprocesses of antibodies, peptides, proteins, blood components and growth factors.
| Canonical Smiles | C1COCCN1CCS(=O)(=O)O.O |
|---|---|
| IUPAC Name | 2-morpholin-4-ylethanesulfonic acid;hydrate |
| InChIKey | MIIIXQJBDGSIKL-UHFFFAOYSA-N |
| INCHI | 1S/C6H13NO4S.H2O/c8-12(9,10)6-3-7-1-4-11-5-2-7;/h1-6H2,(H,8,9,10);1H2 |
| Isomeric SMILES | C1COCCN1CCS(=O)(=O)O.O |
| Alternate CAS | 145224-94-8 |
| Molecular Weight | 195.24 (anhydrous basis) |
| Reaxy-Rn | 6350956 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6350956&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Oxazinanes |
| Subclass | Morpholines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Morpholines |
| Alternative Parents | Sulfonyls Organosulfonic acids Alkanesulfonic acids Trialkylamines Oxacyclic compounds Dialkyl ethers Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aliphatic heteromonocyclic compounds |
| Substituents | Morpholine - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Organosulfonic acid - Sulfonyl - Alkanesulfonic acid - Tertiary amine - Tertiary aliphatic amine - Dialkyl ether - Ether - Oxacycle - Azacycle - Organopnictogen compound - Organic oxygen compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Amine - Aliphatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as morpholines. These are organic compounds containing a morpholine moiety, which consists of a six-member aliphatic saturated ring with the formula C4H9NO, where the oxygen and nitrogen atoms lie at positions 1 and 4, respectively. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 J2529164 | Certificate of Analysis | Nov 03, 2025 | M486599 |
| E2530339 | Certificate of Analysis | Jun 04, 2025 | M486599 |
| E2530340 | Certificate of Analysis | Jun 04, 2025 | M486599 |
| E2407029 | Certificate of Analysis | May 16, 2024 | M486599 |
| Molecular Weight | 213.250 g/mol |
|---|---|
| XLogP3 | |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 3 |
| Exact Mass | 213.067 Da |
| Monoisotopic Mass | 213.067 Da |
| Topological Polar Surface Area | 76.200 Ų |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Complexity | 214.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
| 1. Jie Xiong, Yunfang Xiao, Jiaman Liang, Jian Sun, Lixia Gao, Qiuju Zhou, Dan Hong, Kejun Tan. (2022) Dye-based dual-emission Eu-MOF synthesized by Post-modification for the sensitive ratio fluorescence visualization sensing of ClO-. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:36126623] [10.1016/j.saa.2022.121863] |
| 2. Chunling Nie, Ting Shen, Weicheng Hu, Qin Ma, Jiahui Zhang, Shuqian Hu, Huafeng Tian, Hao Wu, Xiaogang Luo, Jianguo Wang. (2021) Characterization and antibacterial properties of epsilon-poly- l-lysine grafted multi-functional cellulose beads. CARBOHYDRATE POLYMERS, [PMID:33838793] [10.1016/j.carbpol.2021.117902] |
| 3. Ji-Wei Shen, Cheng-Xiong Yang, Lu-Xi Dong, Hao-Ran Sun, Kai Gao, Xiu-Ping Yan. (2013) Incorporation of Computed Tomography and Magnetic Resonance Imaging Function into NaYF4:Yb/Tm Upconversion Nanoparticles for in Vivo Trimodal Bioimaging. ANALYTICAL CHEMISTRY, [PMID:24237132] [10.1021/ac403486r] |
| 4. Yun Hui, Weijun Kong, Weiliang Shu, Zhiting Peng, Fengshan Shen, Mingyang Jiang, Zhen Xu, Tianzhun Wu, Wenhua Zhou, Xue-Feng Yu. (2024) A Biomimetic Chip with Dendrimer-Encapsulated Platinum Nanoparticles for Enhanced Electrochemiluminescence Detection of Cardiac Troponin I. Chemosensors, 12 (10): (214). [PMID:] [10.3390/chemosensors12100214] |
| 5. Shen Long, Meng-Jie Yu, Ran Feng, Han Tao, Bao Zhang. (2024) Novel self-assembled micelles of dual-modified dextrin with pH responsiveness via grafted octenyl succinic anhydride and cysteamine for curcumin delivery. FOOD CHEMISTRY, [PMID:39142209] [10.1016/j.foodchem.2024.140748] |
| 6. Jing Wu, Shuqing Xiang, Ming Zhang, Ninglin Zhou, Mingqian Wang, Li Li, Jian Shen. (2024) Self-Assembled Nanoflowers Realizes Synergistic Sterilization with Photothermal and Chemical Kinetics Therapy. LANGMUIR, [PMID:38265289] [10.1021/acs.langmuir.3c02838] |
| 7. Bao Zhang, Shen Long, Ran Feng, Meng-Jie Yu, Bao-Cai Xu, Han Tao. (2024) Thiolated dextrin nanoparticles for curcumin delivery: Stability, in vitro release, and binding mechanism. FOOD CHEMISTRY, [PMID:39395353] [10.1016/j.foodchem.2024.141501] |
| 8. Ma Xing, Fan Hui, Chen Yuanli. (2025) Porous Silica Nanospheres Grafted with L-Glutamic Acid for Enantioseparation. JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION, 40 (4): (967-974). [PMID:] [10.1007/s11595-025-3134-4] |
