Mestranol - Moligand™, 10mM in DMSO , Estrogen receptor alpha agonist, CAS No.72-33-3, Estrogen receptor alpha agonist

CAS: 72-33-3 Cat. No.: M409226 Summenformel: C₂₁H₂₆O₂ Molekulargewicht: 310.43 Beilstein Registry Number: 2625905 EG-Nummer: 200-777-8

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(17α)​-3-​methoxy-19-​norpregna-​1,​3,​5(10)​-​trien-​20-​yn-​17-​ol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potentestrogen receptoragonist and used as oral contraceptives.
In vitro

Mestranol is extensively metabolized to hydroxylated products whose bio- logical activity is less well characterized.

In vivo

Mestranol (0.2 mg/kg) results in an increased percentage of liver occupied by AHF expressing glutathione S-transferase (PGST) in rats. Mestranol administration increases the focal hepatocyte labeling index compared with the control with a trend at the lower dose and a significant difference at the higher dose. Mestranol (0.02 mg/kg and 0.2 mg/kg diet) results in a decrease in the non-focal labeling index compared with that observed for the corresponding concentration of Mestranol alone. Mestranol significantly increases the non-focal hepatic labeling index in uninitiated rats compared with that observed in rats administered the basal diet only. Mestranol (50 mg/100 g b.wt.) has a significant reduction in the apparent number of alpha-2-adrenoceptors in the frontal cortex and nucleus tractus solitarius (NTS) of rat, while apparent numbers of both alpha-1 and alpha-2-adrenoceptors are depressed in the locus coeruleus.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyme

(17α)​-3-​methoxy-19-​norpregna-​1,​3,​5(10)​-​trien-​20-​yn-​17-​ol

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potent estrogen receptor agonist and used as oral contraceptives.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

AGONIST

Mechanismus der Wirkung

Estrogen receptor alpha agonist

Produkteigenschaften

• ALogP: 4

Namen und Kennungen

• Isomere SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)OC
• WGK Deutschland: 3
• RTECS: RC8960000
• Molekulargewicht: 310.43
• Beilstein: 2625905
• Reaxy-Rn: 8930321
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8930321&ln=

Zugehörige Ziele (menschlich)

ESR1 Tclin Estrogen receptor (2 Activities)

Discover Target: ESR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A4 Tclin Sodium-dependent serotonin transporter (2 Activities)

Discover Target: SLC6A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 31 mg/mL (199.75 mM); Water: Insoluble; Ethanol: Insoluble
• Spezifische Drehung [α]: [α]D：4° (C=2,Dioxane)
• Schmelzpunkt (°C): 151 °C