Methotrexate α-tert-butyl ester - ≥96% , CAS No.79640-70-3

CAS: 79640-70-3 Cat. No.: M649379 Summenformel: C₂₄H₃₀N₈O₅ Molekulargewicht: 510.55

GRADE & PURITY ≥96%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent.

In Vitro

OtBu-MTX-PVG is less HT1080 than MTX-PVG against HT1080 cells. It shows that protection of the α-carboxyl group of MTX results in reduced in vitro activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lys-MTXcleavable- (OtBu) significantly reduces tumor growth in HT1080 tumor bearing mice . The protection of the α-carboxyl group of methotrexate may be used to improve the circulatory half-life and reduce the liver accumulation of similar MTX-conjugated dendrimers, while still retaining antitumor activity in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female, Balb/c nu/nu, 6 weeks (bearing HT1080 cells) Dosage: 30 mg/kg Administration: Once per week for 2 weeks Result: Showed a significant (63%) reduction in tumor size on day 12.

Form:Solid

Specifications

Spezifikationen & Reinheit

≥96%

Biochemische und physiologische Mechanismen

Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥96%

Namen und Kennungen

Molekulargewicht

510.55

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥96% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 79640-70-3, the molecular formula is C24H30N8O5, and the molecular weight is 510.55 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.