10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 6 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Methylthiouracil (NSC-193526, NSC-9378) is an antithyroid agent. Methylthiouracil suppresses the productionTNF-αandIL-6, and the activation ofNF-κBandERK1/2.
In vitro
Methylthiouracil acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland. Methylthiouracil is also used in combination with radioactive iodine.
In vivo
Cell Data
cell lines：MM1.S, MM.1R, LR5, RPMI 8226, DOX40, OPM1, OPM2, INA6, and U266
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomere SMILES | CC1=CC(=O)NC(=S)N1 |
|---|---|
| UN-Nummer | 3077 |
| Verpackungsgruppe | III |
| Molekulargewicht | 142.18 |
| Reaxy-Rn | 115648 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=115648&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Löslichkeit | Solubility (25°C) In vitro DMSO: 64 mg/mL (199.17 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| Schmelzpunkt (°C) | 330°C |
| 1. Xuan Liang, Yi-Heng Gui, Qing-Xian Yue, Rui Ding, Jie Liu, Hai-Bin Yu. (2023) Comparison of inhibition performance of thiadiazole derivatives containing sulfhydryl groups: Experimental and theoretical calculations. INTERNATIONAL JOURNAL OF CHEMICAL KINETICS, 55 (9): (503-524). [PMID:] [10.1002/kin.21652] |
| 2. Zhong‑Lu Ye, Xiao‑Xiao Hou, Re‑Ling Chen, Jie Ding, Guo‑Hua Zheng, Ming‑Zhen Chen, Chuan Tian. (2014) Effects of methylthiouracil on the proliferation and apoptosis of rat bone marrow stromal cells. Experimental and Therapeutic Medicine, 7 (6): (1738-1744). [PMID:24926377] [10.3892/etm.2014.1612] |
| 3. Youlong Chen, Yihua Hu, Yushuang Zhang, Hao Huang, Xing Yang, Youlin Gu, Fanhao Meng, Yuhao Xia, Ziwei Fu, Xinyuan Zhang, Junhao Chu. (2025) Synergistic Enhancement of Fluorescence Through Plasmon Resonance and Interfacial Charge Transfer by AgNC@AgAux Core–Shell Quantum Dots. ADVANCED MATERIALS, [PMID:39901465] [10.1002/adma.202415388] |
| 4. Haishuang Zhu, Jing Li, Jin Wang, Erkang Wang. (2019) Lighting Up the Gold Nanoclusters via Host–Guest Recognition for High-Efficiency Antibacterial Performance and Imaging. ACS Applied Materials & Interfaces, [PMID:31512853] [10.1021/acsami.9b11026] |
| 5. Xiaofan Wang, Xu Zhao, Liqiang Gu, Chunxiao Lv, Bosai He, Zhenzhen Liu, Pengyi Hou, Kaishun Bi, Xiaohui Chen. (2014) Simultaneous determination of five free and total flavonoids in rat plasma by ultra HPLC–MS/MS and its application to a comparative pharmacokinetic study in normal and hyperlipidemic rats. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, [PMID:24566333] [10.1016/j.jchromb.2014.01.042] |
| 6. Xiaofan Wang, Xu Zhao, Liqiang Gu, Yuanyuan Zhang, Kaishun Bi, Xiaohui Chen. (2013) Discrimination of aqueous and vinegary extracts of Shixiao San using metabolomics coupled with multivariate data analysis and evaluation of anti-hyperlipidemic effect. Asian Journal of Pharmaceutical Sciences, [PMID:] [10.1016/j.ajps.2013.11.008] |
