mGluR2 antagonist 1 - 10mM in DMSO , CAS No.1432728-49-8

CAS: 1432728-49-8 Cat. No.: M654562 Summenformel: C₂₁H₁₆FN₃O₃ Molekulargewicht: 377.37 PubChem CID: 71566598

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator ( IC 50 of 9 nM) with excellent brain permeability

In Vivo

In vivo, mGluR2 antagonist 1 (Compound 25) reverses the effect of mGluR2 agonist LY379268 in amphetamine-induced hyperlocomotion and shows good efficacy in the mouse delayed non-match to position assay at 10 mg/kg. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:mGluR2 9 nM (IC 50 )

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator ( IC 50 of 9 nM) with excellent brain permeability.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Isomere SMILES

C1CC(=O)N(C1=O)CC2=CC3=C(C=C2)C(=CC(=N3)C(=O)N)C4=CC=C(C=C4)F

PubChem CID

71566598

Molekulargewicht

377.37

Zugehörige Ziele (menschlich)

GRM2 Tchem Metabotropic glutamate receptor 2 (3 Activities)

Discover Target: GRM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)