10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 6 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Mito-TEMPO Mito-TEMPO (MT), a mitochondria-targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. Mito-TEMPO treatment inhibits APAP-induced RIP3 kinase expression.
Targets
RIP3 kinase
In vitro
Mito-TEMPO improves blastocyst development by superoxide reduction in porcine embryos in vitro.
In vivo
Mito-Tempo (MT) treatment inhibits APAP-induced RIP3 kinase expression, and RIP3-deficient mice shows caspase activation and apoptotic morphology in hepatocytes analogous to MT treatment.
Cell Research(from reference)
Cell lines：Porcine embryos
Concentrations：0.1\u2009μM
| Pubchem Sid | 528772803 |
|---|---|
| Kanonisches Lächeln | CC1(CC(CC(N1O)(C)C)NC(=O)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C.[Cl-] |
| IUPAC Name | [2-[(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-oxoethyl]-triphenylphosphanium;chloride |
| InChIKey | QJEOOHMMSUBNGG-UHFFFAOYSA-N |
| INCHI | 1S/C29H35N2O2P.ClH/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;/h5-19,23,33H,20-22H2,1-4H3;1H |
| WGK Deutschland | 3 |
| Molekulargewicht | 511 |
| Reaxy-Rn | 34662187 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=34662187&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| 1. Xi Yan, Yinghao Niu, Yaojie Wang, Sisi Wei, Lina Han, Zhongyu Guo, Lianmei Zhao, Feng Gao. (2025) CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis. Open Medicine, 20 (1): [PMID:39822985] [10.1515/med-2024-1100] |
| 2. Guo Junchen, Wang Shanjie, Wan Xin, Liu Xiaoxuan, Wang Zeng, Liang Chenchen, Zhang Zhenming, Wang Ye, Yan Miao, Wu Pengyan, Fang Shaohong, Yu Bo. (2024) Mitochondria-derived methylmalonic acid aggravates ischemia–reperfusion injury by activating reactive oxygen species-dependent ferroptosis. Cell Communication and Signaling, 22 (1): (1-20). [PMID:38238728] [10.1186/s12964-024-01479-z] |
| 3. Nan Wang, Zhengshan Gao, Honghong Zhan, Lin Jing, Fancheng Meng, Min Chen. (2025) Salidroside alleviates doxorubicin-induced hepatotoxicity via Sestrin2/AMPK-mediated pyroptotic inhibition. FOOD AND CHEMICAL TOXICOLOGY, [PMID:39993461] [10.1016/j.fct.2025.115335] |
| 4. Dong Han, Yun-Biao Chen, Kai Zhao, Hong-Zhou Li, Xing-Yu Chen, Guo-Zheng Zhu, Chen Tu, Jia-Wen Gao, Jing-Shen Zhuang, Zhi-Yong Wu, Zhao-Ming Zhong. (2024) Tanshinone IIA alleviates inflammation-induced skeletal muscle atrophy by regulating mitochondrial dysfunction. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, [PMID:39547552] [10.1016/j.abb.2024.110215] |
| 5. Li Xingyu, Tang Zhaoxia, Kuang Liangjian, Wu Yongjian, Huang Xi. (2025) Platelet membrane-coated nanoparticles inhibit platelet activation and neutrophil extracellular traps formation in acute lung injury. Journal of Translational Medicine, 23 (1): (1-15). [PMID:40713829] [10.1186/s12967-025-06649-2] |
| 6. Binxu Yin, Wentong Tang, Yan Hu, Yuwei Li, Hao Cai, Maocheng Zuo, Lujia Xiao, Tong Xu, Jia Li, Jingwei Hu, Ji-Feng Fei, Heng Wang. (2026) Divergent redox states define regenerative outcomes between salamanders and Xenopus. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:41932458] [10.1016/j.freeradbiomed.2026.04.001] |
