Mitomycin C - 10mM in DMSO , CAS No.50-07-7

CAS: 50-07-7 Cat. No.: M407788 Summenformel: C₁₅H₁₈N₄O₅ Molekulargewicht: 334.33 Beilstein Registry Number: 7231816 EG-Nummer: 200-008-6

GRADE & PURITY 10mM in DMSO

Synonyms

KBioGR_000607 | Mytozytrex | KBio2_003175 | Mitomycin (TN) | NSC 26980 | UGN-102 | [(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate | 50-07-7 (non-salt) | Aziri

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs,FedEx DG Service

Übersicht

Information

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.
In vitro

Mitomycin C, by inducing DNA interstrand crosslinks, physically blocks DNA replication, recombination, and RNA transcription. ^[1] Mitomycin C potentiates TRAIL-induced apoptosis in HCT116 (p53-/-) colon cancer cells and sensitizes TRAIL-resistant colon cancer cells HT-29 to the cytokine by through JNK-independent upregulation of death receptors. ^[2] In different human cancer cell lines, such OVCAR-5 (ovary), HT-29 (colon), SK-N-MC (neuroblastoma), HEP-2 (liver), COLO-205 (colon), NIH-OVCAR-3 (ovary) and A-549 (lung) cells, Mitomycin C shows cytotoxic activity.

In vivo

As the clinical first choice in superficial bladder tumors, in a rat bladder tumor model, Mitomycin C (400 μM) significantly prevents intravesical tumor growth.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Synonyme

KBioGR_000607 | Mytozytrex | KBio2_003175 | Mitomycin (TN) | NSC 26980 | UGN-102 | [(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate | 50-07-7 (non-salt) | Aziri

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs,FedEx DG Service

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Produkteigenschaften

ALogP

-0.4

Namen und Kennungen

Isomere SMILES

CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N

WGK Deutschland

3

Alternative CAS-Nummer

1404-00-8

UN-Nummer

2811

Verpackungsgruppe

I

Molekulargewicht

334.33

Beilstein

7231816

Reaxy-Rn

630306

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=630306&ln=

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro Water: 97 mg/mL (200.25 mM); DMSO: Insoluble; Ethanol: Insoluble
• Empfindlichkeit: Light & Heat & Moisture sensitive
• Brechungsindex: 1.68 (Predicted)
• Siedepunkt (°C): 581.8° C at 760 mmHg (Predicted)
• Schmelzpunkt (°C): 64℃

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 50-07-7, the molecular formula is C15H18N4O5, and the molecular weight is 334.33 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.