Mitomycin C - 10mM in DMSO , CAS No.50-07-7

CAS: 50-07-7 Cat. No.: M407788 Molecular Weight: 334.33 Beilstein Registry Number: 7231816 EC Number: 200-008-6

GRADE & PURITY 10mM in DMSO

Synonyms

KBioGR_000607 | Mytozytrex | KBio2_003175 | Mitomycin (TN) | NSC 26980 | UGN-102 | [(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate | 50-07-7 (non-salt) | Aziri

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs,FedEx DG Service

Overview

Information

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.
In vitro

Mitomycin C, by inducing DNA interstrand crosslinks, physically blocks DNA replication, recombination, and RNA transcription. ^[1] Mitomycin C potentiates TRAIL-induced apoptosis in HCT116 (p53-/-) colon cancer cells and sensitizes TRAIL-resistant colon cancer cells HT-29 to the cytokine by through JNK-independent upregulation of death receptors. ^[2] In different human cancer cell lines, such OVCAR-5 (ovary), HT-29 (colon), SK-N-MC (neuroblastoma), HEP-2 (liver), COLO-205 (colon), NIH-OVCAR-3 (ovary) and A-549 (lung) cells, Mitomycin C shows cytotoxic activity.

In vivo

As the clinical first choice in superficial bladder tumors, in a rat bladder tumor model, Mitomycin C (400 μM) significantly prevents intravesical tumor growth.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Synonyms

KBioGR_000607 | Mytozytrex | KBio2_003175 | Mitomycin (TN) | NSC 26980 | UGN-102 | [(1aS, 8S, 8aR, 8bS)-6-amino-8a-methoxy-5-methyl-4, 7-dioxo-1, 1a, 2, 4, 7, 8, 8a, 8b-octahydroazireno[2', 3':3, 4]pyrrolo[1, 2-a]indol-8-yl]methyl carbamate | 50-07-7 (non-salt) | Aziri

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs, FedEx DG Service

This product requires cold chain shipping. Ground and other economy services are not available.

Product Properties

• ALogP: -0.4

Names and Identifiers

• Isomeric SMILES: CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
• WGK Germany: 3
• Alternate CAS: 1404-00-8
• UN Number: 2811
• Packing Group: I
• Molecular Weight: 334.33
• Beilstein: 7231816
• Reaxy-Rn: 630306
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=630306&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro Water: 97 mg/mL (200.25 mM); DMSO: Insoluble; Ethanol: Insoluble
• Sensitivity: Light & Heat & Moisture sensitive
• Refractive Index: 1.68 (Predicted)
• Boil Point(°C): 581.8° C at 760 mmHg (Predicted)
• Melt Point(°C): 64℃

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