ML 67-33 - ≥98% , CAS No.1443290-89-8

CAS: 1443290-89-8 Cat. No.: M288094 Summenformel: C₁₈H₁₇Cl₂N₅ Molekulargewicht: 374.27 PubChem CID: 86272454

GRADE & PURITY ≥98%

Synonyms

10-(2-(1H-Tetrazol-5-yl)ethyl)-2,7-dichloro-9,9-dimethyl-9,10-dihydroacridine | 2,7-Dichloro-9,9-dimethyl-10-[2-(1H-tetrazol-5-yl)-ethyl]-9,10-dihydro-acridine

Storage

Lagerung bei -20°C, Argon geladen

Shipped In

Eistruhe + Eispads

Übersicht

ML67-33 wirkt schnell und reversibel auf K2P2.1 (TREK-1) (EC50s: 36,3 μM und 9,7 μM in zellfreien bzw. HEK293-Zellen). ML67-33 ist ein selektiver Aktivator von temperatur- und mechanosensitiven K2P-Kanälen.

Specifications

Synonyme

10-(2-(1H-Tetrazol-5-yl)ethyl)-2,7-dichloro-9,9-dimethyl-9,10-dihydroacridine | 2,7-Dichloro-9,9-dimethyl-10-[2-(1H-tetrazol-5-yl)-ethyl]-9,10-dihydro-acridine

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

K2P-Kaliumkanal-Aktivator (EC50-Werte sind 21,8 - 29,4 μM, 30,2 μM und 27,3 μM für K2P2.1 (TREK-1), K2P10.1 (TREK-2) bzw. K2P4.1 (TRAAK), exprimiert in Xenopus-Oocyten). Erhöht die Kanalströme durch Aktivierung des Kern-Gating-Apparats von Chan

Storage

Lagerung bei -20°C, Argon geladen

Verschickt in

Eistruhe + Eispads

Aktionsart

ACTIVATOR

Reinheit

≥98%

Namen und Kennungen

• Kanonisches Lächeln: CC1(C2=C(C=CC(=C2)Cl)N(C3=C1C=C(C=C3)Cl)CCC4=NNN=N4)C
• IUPAC Name: 2,7-dichloro-9,9-dimethyl-10-[2-(2H-tetrazol-5-yl)ethyl]acridine
• InChIKey: GQPMJOXQJUGJPG-UHFFFAOYSA-N
• INCHI: 1S/C18H17Cl2N5/c1-18(2)13-9-11(19)3-5-15(13)25(8-7-17-21-23-24-22-17)16-6-4-12(20)10-14(16)18/h3-6,9-10H,7-8H2,1-2H3,(H,21,22,23,24)
• Isomere SMILES: CC1(C2=C(C=CC(=C2)Cl)N(C3=C1C=C(C=C3)Cl)CCC4=NNN=N4)C
• PubChem CID: 86272454
• Molekulargewicht: 374.27

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Quinolines and derivatives
      • Subclass Benzoquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Quinolines and derivatives
• Subclass: Benzoquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Acridines
• Alternative Parents: Alkyldiarylamines Aralkylamines Benzenoids Aryl chlorides Tetrazoles Heteroaromatic compounds Azacyclic compounds Organochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Acridine - Alkyldiarylamine - Tertiary aliphatic/aromatic amine - Aralkylamine - Benzenoid - Aryl halide - Aryl chloride - Heteroaromatic compound - Tetrazole - Azole - Tertiary amine - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Organochloride - Organohalogen compound - Amine - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as acridines. These are organic compounds containing the acridine moiety, a linear tricyclic heterocycle which consists of two benzene rings joined by a pyridine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

KCNK2 Tclin Potassium channel subfamily K member 2 (7 Activities)

Discover Target: KCNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK10 Tclin Potassium channel subfamily K member 10 (76 Activities)

Discover Target: KCNK10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNK18 Tclin Potassium channel subfamily K member 18 (30 Activities)

Discover Target: KCNK18

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNK4 Tbio Potassium channel subfamily K member 4 (18 Activities)

Discover Target: KCNK4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zugehörige Ziele (nicht menschlich)

Kcnq2 Voltage-gated potassium channel subunit Kv7.2 (95 Activities)

Discover Target: Kcnq2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Kcnk3 Potassium channel subfamily K member 3 (21 Activities)

Discover Target: Kcnk3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Kcnk9 Potassium channel subfamily K member 9 (8 Activities)

Discover Target: Kcnk9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNK2 Potassium channel subfamily K member 2 (9 Activities)

Discover Target: KCNK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Solvent:DMSO, Max Conc. mg/mL: 37.43, Max Conc. mM: 100
• Molekulargewicht: 374.300 g/mol
• XLogP3: 5.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 373.086 Da
• Monoisotopic Mass: 373.086 Da
• Topological Polar Surface Area: 57.700 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 446.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1443290-89-8, the molecular formula is C??H??Cl?N?, and the molecular weight is 374.27 g/mol. InChIKey GQPMJOXQJUGJPG-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.