ML401 - Moligand™,10mM in DMSO , CAS No.1597489-14-9

CAS: 1597489-14-9 Cat. No.: M655581 Summenformel: C₂₀H₂₀BrClN₂O Molekulargewicht: 419.7 PubChem CID: 73169083

QUALITÄT & REINHEIT Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183 ) with an IC 50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC 50 =6.24 nM). ML401 shows good stability and no toxicity

In Vitro

ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ML401 shows very good stability in both human plasma and mouse plasma . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 1.03 nM (EBI2)

Spezifikationen

Spezifikationen & Reinheit

Moligand™,10mM in DMSO

Biochemische und physiologische Mechanismen

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183 ) with an IC 50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC 50 =6.24 nM). ML401 shows good stability and no toxicity.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

ANTAGONIST

Namen und Kennungen

Isomere SMILES

C1CN(CCN1CC2=CC=C(C=C2)Cl)C(=O)/C=C/C3=CC=C(C=C3)Br

PubChem CID

73169083

Molekulargewicht

419.7

Zugehörige Ziele (menschlich)

GPR183 Tchem G-protein coupled receptor 183 (2 Activities)

Discover Target: GPR183

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Häufig gestellte Fragen

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1597489-14-9, the molecular formula is C20H20BrClN2O, and the molecular weight is 419.7 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.