MLS-0437605 - 10mM in DMSO , CAS No.862975-18-6

CAS: 862975-18-6 Cat. No.: M654709 Molecular Weight: 342.35

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC 50 of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs).

In Vitro

MLS-0437605 efficiently inhibits platelet aggregation in response to collagen related peptide (CRP) and rhodocytin, but not after stimulation with thromboxane. MLS-0437605 causes a decrease in pY of a ~70-kDa band after stimulation with CRP or rhodocytin. Tyrosine phosphorylation of immunoprecipitated Syk and PLCγ2 is also reduced by MLS-0437605. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC 50 of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs).

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Molecular Weight: 342.35