MLS000544460 - 10mM in DMSO , CAS No.352336-36-8

CAS: 352336-36-8 Cat. No.: M655800 Summenformel: C₁₇H₁₂FN₃O₂S Molekulargewicht: 341.36 PubChem CID: 7285259

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a K d of 2.0 μM and an IC 50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity

In Vitro

MLS000544460 does not bind Eya3 phosphatase (ED). MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells. When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg 2+ , it binds MLS000544460 with a higher affinity (K d =0.80 μM), indicating that this class of compounds does not require Mg 2+ for its interaction with the Eya2 ED. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Kd: 2.0 μM (Eya2 phosphatase), IC50: 4 μM (Eya2 phosphatase)

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a K d of 2.0 μM and an IC 50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

• Isomere SMILES: C1=CC=NC(=C1)SC2=CC=C(O2)/C=N/NC(=O)C3=CC(=CC=C3)F
• PubChem CID: 7285259
• Molekulargewicht: 341.36

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 352336-36-8, the molecular formula is C17H12FN3O2S, and the molecular weight is 341.36 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.