MLS000544460 - 10mM in DMSO , CAS No.352336-36-8

CAS: 352336-36-8 Cat. No.: M655800 Molecular Weight: 341.36 PubChem CID: 7285259

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a K d of 2.0 μM and an IC 50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity

In Vitro

MLS000544460 does not bind Eya3 phosphatase (ED). MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells. When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg 2+ , it binds MLS000544460 with a higher affinity (K d =0.80 μM), indicating that this class of compounds does not require Mg 2+ for its interaction with the Eya2 ED. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Kd: 2.0 μM (Eya2 phosphatase), IC50: 4 μM (Eya2 phosphatase)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a K d of 2.0 μM and an IC 50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: C1=CC=NC(=C1)SC2=CC=C(O2)/C=N/NC(=O)C3=CC(=CC=C3)F
• PubChem CID: 7285259
• Molecular Weight: 341.36