MMAD-d8 - ≥98% , CAS No.M659002

CAS: M659002 Cat. No.: M659002 Molecular Weight: 779.11

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

MMAD-d 8 D is a deuterated form of MMAD, which is a microtubule disrupting agent.

Appearance:Solid

IC50& Target:Auristatin

In Vitro:MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties

In Vivo:The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biological Activity:MMAD-d 8 D is a deuterated form of MMAD, which is a microtubule disrupting agent.

Specifications

Specifications & Purity

≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: O=C(N[C@H](C1=NC=CS1)CC2=CC=CC=C2)[C@H](C)[C@@H](OC)[C@H]3N(C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@](C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])([2H])NC([C@H](C(C)C)NC)=O)=O)C)=O)CCC3
• Molecular Weight: 779.11

Chemical and Physical Properties

• Solubility: DMSO : ≥ 100 mg/mL (128.35 mM)