Monosodium urate (PBS solution) - 2 wt％ , CAS No.1198-77-2

CAS: 1198-77-2 Cat. No.: M276559 Summenformel: C₅H₃N₄O₃Na Molekulargewicht: 190.09

GRADE & PURITY 2 wt％

Synonyms

NCGC00181049-01 | AS-80123 | Uric acid sodium salt | Uric acid monosodium salt (crystals) | Monosodium urate (crystals) | CID 16220071 | SCHEMBL229866

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Übersicht

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

The product is a PBS solution, packaged based on solute content. Shake evenly before use.

Specifications

Synonyme

NCGC00181049-01 | AS-80123 | Uric acid sodium salt | Uric acid monosodium salt (crystals) | Monosodium urate (crystals) | CID 16220071 | SCHEMBL229866

Spezifikationen & Reinheit

2 wt％

Biochemische und physiologische Mechanismen

NLRP3/NALP3 inflammasome activator. Stimulates caspase-1 activating NLRP3/NALP3 inflammasome, results in active IL-1β and IL-18 production. Active in vitro and in vivo .

Storage

Store at -20°C,Desiccated

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Namen und Kennungen

• Kanonisches Lächeln: C12=C(NC(=O)N1)NC(=O)NC2=O.[Na]
• InChIKey: XDKLKFULWJYRCB-UHFFFAOYSA-N
• INCHI: 1S/C5H4N4O3.Na/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;/h(H4,6,7,8,9,10,11,12)
• Isomere SMILES: C12=C(NC(=O)N1)NC(=O)NC2=O.[Na]
• Molekulargewicht: 190.09
• Reaxy-Rn: 24218033
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24218033&ln=

Referenzen

1. Jiang Yanan, Zhang Chengyi, Zhang Xinyue, Lan Na, Zhao Zihan, Xv Yawei, Wang Qi, Wang Siwei, Chen Baifeng, Chen Xi, Wang Yilin.  (2024)  Antigout effects and mechanisms of total flavonoids from prunus tomentosa.  TECHNOLOGY AND HEALTH CARE,      [PMID:38759051] [10.3233/THC-248019]

2. Du Li, Jindian Dong, Tong Xiong, Xingyu Zhou, Yanhui Li, Chuncheng Chen, Shijie Li, Zhuoyue Song, Nenggui Xu, Mingjing Yang, Xiaoxia Yan, Tao Liu, Shihui Liu.  (2024)  Transdermal delivery of iguratimod and colchicine ethosome by dissolving microneedle patch for the treatment of recurrent gout.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:39003846] [10.1016/j.colsurfb.2024.114087]

3. Yu Dong-hua, Wang Yu, Yu Chun-Miao, Zhou Qi, Liu Shu-min, Liu Ting-ting.  (2025)  Construction of ceRNA networks in joint tissues of gouty arthritis rats based on transcriptome sequencing.  AIP Advances,  15  (7):   [PMID:] [10.1063/5.0271292]

4. Xiaomin Xu, Donghua Yu, Yu Wang, Peng Xu, Xin Jiang, Fang Lu, Shumin Liu.  (2024)  Integrating network pharmacology and renal metabonomics to reveal the protective mechanism of resveratrol on gouty nephropathy.  BIOMEDICAL CHROMATOGRAPHY,      [PMID:38402638] [10.1002/bmc.5839]

5. Xiaomin Xu, Donghua Yu, Yu Wang, Xin Jiang, Fang Lu, Shumin Liu.  (2024)  Investigating the mechanisms of resveratrol in the treatment of gouty arthritis through the integration of network pharmacology and metabolics.  Frontiers in Endocrinology,      [PMID:39534253] [10.3389/fendo.2024.1438405]

6. Wenyan Guo, Yi Yang, Guangyuan Liu, Jiaojiao Zhao, Yuyu Zhang, Yahui Li, Bingkun Yang, Xiaoque Zhu, Dandan Li, Xia Qin, Panpan Zhang, Zuxiao Yang, Wei Guo, Dezhi Kong, Wei Zhang.  (2025)  The Anti-Neuroinflammatory Effects of Cepharanthine in Uric Acid-Induced Neuroinflammation.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:39870338] [10.1016/j.jep.2025.119409]

7. Wei Zhang, Xiangbing Wu, Wenming Li, Haifeng Zhang, Yijun Wang, Jing Xu, Wenhao Li, Yi Qin, Zebin Wu, Gaoran Ge, Shujun Lv, Lu Mao, Liangliang Wang, Dechun Geng.  (2025)  Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome.  Advanced Science,      [PMID:40492417] [10.1002/advs.202501532]

8. Na Wang, Puchen Zhao, Qin Yin, Lizi Li, Haiqi Xu, Can Yang, Yanbei Tu, Yanfang Li.  (2025)  Shi Wei Ru Xiang pill alleviates acute gouty arthritis through suppressing NLRP3 inflammasome activation.  Frontiers in Pharmacology,      [PMID:40635741] [10.3389/fphar.2025.1595578]

9. Jian Zhang, Xiaqian Xu, Anqi Zhu, Jie He, Guangrui Liu, Ting Cui, Yanna Lin, Yijing Wang, Guisen Zhang, Chao Hao.  (2026)  Step-by-step optimization of a colchicine-loaded nanoemulgel for superior topical therapy of acute gouty arthritis.  JOURNAL OF PHARMACEUTICAL SCIENCES,      [PMID:42437588] [10.1016/j.xphs.2026.104415]