Mps1-IN-3 - 10mM in DMSO , CAS No.1609584-72-6

CAS: 1609584-72-6 Cat. No.: M654799 Molecular Weight: 537.63 PubChem CID: 91885443

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC 50 of 50 nM.

In Vitro

Mps1-IN-3 is a potent MPS1 kinase inhibitor, with an IC 50 of 50 nM. Mps1-IN-3 inhibits the proliferation of U251 glioblastoma cells with an IC 50 of appr 5 µM. Mps1-IN-3 (2 μM) can completely abrogates checkpoint. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mps1-IN-3 (2 mg/kg, i.v.) sensitizes glioblastoma cells in murine tumor models, with prolonged survival and no toxicity . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Mps1 50 nM (IC 50 )

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC 50 of 50 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC3=C2NC=N3)NC4=C(C=C(C=C4)N5CCC(CC5)O)OC
• PubChem CID: 91885443
• Molecular Weight: 537.63