MRK-740 - 10mM in DMSO , CAS No.2387510-80-5

CAS: 2387510-80-5 Cat. No.: M656223 Molecular Weight: 464.56 PubChem CID: 137331596

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC 50 of 80 nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9 -dependent trimethylation of H3K4 ( IC 50 = 0.8 µM)

In Vitro

After 24?h of treatment, MRK-740 (3?μM) does not affect HEK293T cell growth at the IC 90 , but some toxicity is observed at 10?μM. MRK-740 is an equipotent inhibitor of H3K4 methylation in MCF7 cells. In cells, MRK-740 specifically and directly inhibits H3K4 methylation at endogenous PRDM9 target loci. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 80 nM (PRDM9)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC 50 of 80u2009nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC1=NC=CC(=C1)N2CCC3(CC2)CN(CCN3C)C4=NC(=NO4)C5=CC(=CC(=C5)OC)OC
• PubChem CID: 137331596
• Molecular Weight: 464.56