MRS2279 diammonium - ≥98% , CAS No.2387505-47-5

CAS: 2387505-47-5 Cat. No.: M648204 Summenformel: C₁₃H₂₄ClN₇O₈P₂ Molekulargewicht: 503.77

GRADE & PURITY ≥98%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Übersicht

MRS2279 diammonium is a selective and high affinity P2Y1 receptor antagonist, with a K i value of 2.5 nM and an IC 50 value of 51.6 nM. MRS2279 diammonium competitively inhibits ADP-promoted platelet aggregation with an pK b value of 8.05

In Vitro

MRS2279 diammonium antagonizes 2-MeSADP-stimulated inositol phosphate formation in turkey erythrocyte membranes with a pK b value of 7.75. MRS2279 diammonium shows high affinity competitive antagonism to human P2Y1 receptor with a pK b value of 8.10 in 1321N1 human astrocytoma cells. MRS2279 diammonium shows specific effect for the P2Y1 receptor, but shows no effect on activation of the human P2Y2, P2Y4, P2Y6, or P2Y11 receptors by their cognate agonists. MRS2279 diammonium shows no ability to block the capacity of ADP to act through the Gi/adenylyl cyclase linked P2Y receptor of platelets to inhibit cyclic AMP accumulation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MRS2279 diammonium (2 μL, 1 nM; intracerebroventricular injection; 30 min prior to mechanical ventilation) reduces mouse brain injury induced by mechanical ventilation in high-pressure ventilation mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:P2Y1 Receptor 51.6 nM (IC 50 )

Specifications

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

MRS2279 diammonium is a selective and high affinity P2Y1 receptor antagonist, with a K i value of 2.5 nM and an IC 50 value of 51.6 nM. MRS2279 diammonium competitively inhibits ADP-promoted platelet aggregation with an pK b value of 8.05.

Storage

Store at -20°C,Desiccated

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

ANTAGONIST

Reinheit

≥98%

Namen und Kennungen

Molekulargewicht

503.77

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2387505-47-5, the molecular formula is C13H24ClN7O8P2, and the molecular weight is 503.77 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.