MSC1094308 - 10mM in DMSO , CAS No.2219320-08-6

CAS: 2219320-08-6 Cat. No.: M656634 Summenformel: C₂₉H₂₉F₃N₂ Molekulargewicht: 462.5 PubChem CID: 139035043

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC 50 values of 0.71 μM and 7.2 μM for VPS4B and p97 , respectively MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97 . MSC1094308 can be used in study of cancer

In Vitro

MSC1094308 (10 µM; 8 h) induces accumulation of polyubiquitin as a biomarker for degradation inhibition in HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HCT116 cells Concentration: 10 µM Incubation Time: 8 h Result: Led to accumulation of polyubiquitinated proteins (a biomarker for degradation inhibition).

IC50& Target:IC50: 0.71 μM (VPS4B), 7.2 μM (p97)

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC 50 values of 0.71 μM and 7.2 μM for VPS4B and p97 , respectively. MSC1094308 inhibits the D2 ATPase activity by binding to a agentable

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

• Isomere SMILES: C1CC2=C(CC1CNCCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C5=C(N2)C=CC(=C5)F
• PubChem CID: 139035043
• Molekulargewicht: 462.5

Zugehörige Ziele (menschlich)

VPS4B Tchem Vacuolar protein sorting-associated protein 4B (2 Activities)

Discover Target: VPS4B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2219320-08-6, the molecular formula is C29H29F3N2, and the molecular weight is 462.5 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.