≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 11 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
description：
N-tert-Butylacrylamide (nTBA) belongs to the class of hydrophobic acrylamides which can be synthesized by Ritter reaction and optimized by using N-tert-butyl acetate and acetic acid.
application：
nTBA is temperature sensitive monomers that can be potentially used in drug delivery systems, dewatering of proteins, and immobilization of cells. It can be used in the preparation of poly(nTBA) based copolymeric hydrogels for bovin serum albumin.
| Pubchem Sid | 488180593 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488180593 |
| Canonical Smiles | CC(C)(C)NC(=O)C=C |
| IUPAC Name | N-tert-butylprop-2-enamide |
| InChIKey | XFHJDMUEHUHAJW-UHFFFAOYSA-N |
| INCHI | 1S/C7H13NO/c1-5-6(9)8-7(2,3)4/h5H,1H2,2-4H3,(H,8,9) |
| Isomeric SMILES | CC(C)(C)NC(=O)C=C |
| WGK Germany | 3 |
| RTECS | AS3460000 |
| Molecular Weight | 127.18 |
| Beilstein | 1742331 |
| Reaxy-Rn | 1742331 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1742331&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Carboxylic acids and derivatives |
| Subclass | Acrylic acids and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Acrylic acids and derivatives |
| Alternative Parents | Secondary carboxylic acid amides Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | Acrylic acid or derivatives - Secondary carboxylic acid amide - Carboxamide group - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as acrylic acids and derivatives. These are organic compounds containing acrylic acid CH2=CHCO2H or a derivative thereof. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 E2627059 | Certificate of Analysis | Jun 06, 2026 | B109092 |
| E2612057 | Certificate of Analysis | May 20, 2026 | B109092 |
| D2403023 | Certificate of Analysis | Jan 19, 2026 | B109092 |
| G2219089 | Certificate of Analysis | Jan 19, 2026 | B109092 |
| G2219090 | Certificate of Analysis | Jan 19, 2026 | B109092 |
| G2219088 | Certificate of Analysis | Jan 19, 2026 | B109092 |
| G2219087 | Certificate of Analysis | Jan 19, 2026 | B109092 |
| F2505055 | Certificate of Analysis | Jun 13, 2025 | B109092 |
| C1827147 | Certificate of Analysis | May 07, 2025 | B109092 |
| E2325165 | Certificate of Analysis | Feb 11, 2025 | B109092 |
| L2405492 | Certificate of Analysis | Jul 12, 2024 | B109092 |
| L2405500 | Certificate of Analysis | Jul 12, 2024 | B109092 |
| G2219116 | Certificate of Analysis | Apr 07, 2024 | B109092 |
| I2104102 | Certificate of Analysis | Jun 07, 2023 | B109092 |
| I2104100 | Certificate of Analysis | Jun 07, 2023 | B109092 |
| I2104101 | Certificate of Analysis | Jun 07, 2023 | B109092 |
| J1727036 | Certificate of Analysis | Apr 11, 2023 | B109092 |
| Solubility | Solubility in Methanol almost transparency |
|---|---|
| Melt Point(°C) | 126-129°C |
| Molecular Weight | 127.180 g/mol |
| XLogP3 | 1.100 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 2 |
| Exact Mass | 127.1 Da |
| Monoisotopic Mass | 127.1 Da |
| Topological Polar Surface Area | 29.100 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 121.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Wenfang Du, Jie Liu, Hong Li, Chenyi Deng, Jie Luo, Qianqian Feng, Yan Tan, Shengyuan Yang, Zhaoyang Wu, Fubing Xiao. (2023) Competition-Based Two-Dimensional Photonic Crystal Dually Cross-Linked Supramolecular Hydrogel for Colorimetric and Fluorescent Dual-Mode Sensing of Bisphenol A. ANALYTICAL CHEMISTRY, [PMID:36786428] [10.1021/acs.analchem.2c05662] |
| 2. Peiyan Shen, Yuqing Shi, Ran Li, Bo Han, Haojie Ma, Xueyan Hou, Yuqi Zhang, Lei Jiang. (2022) Multi-Factors Cooperatively Actuated Photonic Hydrogel Aptasensors for Facile, Label-Free and Colorimetric Detection of Lysozyme. Biosensors-Basel, 12 (8): (662). [PMID:36005058] [10.3390/bios12080662] |
| 3. Muntadher M. Alwan Almijbilee, Yifei Wang, Mao Peng, Aiqun Kong, Jinli Zhang, Wei Li. (2021) Ion-binding ameliorates the organic solvents nanofiltration performance of poly (butyl acrylamide-co-divinylbenzene) composites. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2021.119629] |
| 4. Fen Ran, Jiayu Wu, Xiaoqin Niu, Dan Li, Chuanxiong Nie, Rui Wang, Weifeng Zhao, Weijie Zhang, Yuhong Chen, Changsheng Zhao. (2018) A new approach for membrane modification based on electrochemically mediated living polymerization and self-assembly of N-tert-butyl amide- and β-cyclodextrin-involved macromolecules for blood purification. Materials Science & Engineering C-Materials for Biological Applications, [PMID:30573233] [10.1016/j.msec.2018.10.075] |
| 5. Xinyu Hu, Yongmei Wang, Liangliang Zhang, Man Xu, Jianfa Zhang, Wei Dong. (2018) Photopatterned salecan composite hydrogel reinforced with α-Mo2C nanoparticles for cell adhesion. CARBOHYDRATE POLYMERS, [PMID:30143112] [10.1016/j.carbpol.2018.07.005] |
| 6. Haokun Cai, Liping Liu, Qiang Chen, Ping Lu, Jian Dong. (2016) Ni-polymer nanogel hybrid particles: A new strategy for hydrogen production from the hydrolysis of dimethylamine-borane and sodium borohydride. ENERGY, [PMID:] [10.1016/j.energy.2016.01.046] |
| 7. Liang Liu, Ting Zhong, Qingqing Xu, Yun Chen. (2015) Efficient Molecular Imprinting Strategy for Quantitative Targeted Proteomics of Human Transferrin Receptor in Depleted Human Serum. ANALYTICAL CHEMISTRY, [PMID:26496531] [10.1021/acs.analchem.5b02633] |
| 8. Yingshuang Meng, Lingfeng Wang, Guangming Zhao, Jibo Diao, Zhibo Qi, Mingyang Yu, Zhonghua Li, Yuchao Niu, Gaohong He, Xiaobin Jiang. (2024) Hydrogel Nanoparticles Enable Nucleation Barrier Regulation and Ion Anchoring as an Alternative Pathway for Monosodium Urate Monohydrate Crystallization Control. ACS Nano, [PMID:38741414] [10.1021/acsnano.4c02040] |
| 9. Lu Cui, Juan Wang, Menglin Liu, Wenxin Fan, Kunyan Sui. (2024) In Situ Growth of Multiresponsive Structural Color Patterns within Hydrogels for Multiple Information Encryption. ACS Applied Materials & Interfaces, [PMID:39692293] [10.1021/acsami.4c17805] |
| 10. Yao Li, Ming Zhang, Linjun Li, Kenneth J. Shea, Lingling Kang, Zihui Meng, Min Xue. (2024) Integrating synthetic hydrogel nanoparticles with carbon dots for selective detection of hemoglobin. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2024.136672] |
| 11. Jintang Wang, Qi Wang, Bo Liao, Zhe Sun, Yujing Bai, Ke Zhao, Qian Zheng, Juyuan Zhang, Kaihe Lv, Jinsheng Sun. (2025) Optimizing the Performance of Natural Gas Hydrate Inhibitors: Modifying the Alkyl Size in N-Alkyl Acrylamide. ENERGY & FUELS, [PMID:] [10.1021/acs.energyfuels.5c03476] |
