Nampt-IN-5 - 10mM in DMSO , CAS No.2380013-17-0

CAS: 2380013-17-0 Cat. No.: N656732 Summenformel: C₂₅H₂₅N₅O₂ Molekulargewicht: 427.50 PubChem CID: 146014464

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively

In Vitro

Nampt-IN-5 (compound 27) (0-10 nM; 3 days) has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively. Nampt-IN-5 shows a good ADME data: mouse microsomal clearance (110 μl/min•mg), CYP3A4 inhibition value (0.75 μM), Sol 6.8 : 0.056 mM; MDCK P app AB: 18.6. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nampt-IN-5 (5-30 mg/kg; p.o. twice daily for 4 days) causes a significant amount of body weight loss in nude mice relative to vehicle . Nampt-IN-5 (10 mg/kg; p.o.) exhibits T 1/2 (2.1 h), C max (29112 nM), and AUC (61984 nM•h) in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:NAMPT, CYP3A4

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

Isomere SMILES

CCOC1=NC2=CC=CC=C2N1CC3=CC=C(C=C3)NC(=O)N4CC(C4)C5=CN=CC=C5

PubChem CID

146014464

Molekulargewicht

427.50

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2380013-17-0, the molecular formula is C25H25N5O2, and the molecular weight is 427.50 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.